A positive impact on the serum lipid profile and cytokines after the consumption of a plant sterol-enriched beverage with a milk fat globule membrane: a clinical study
The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple d...
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| Published in | Food & function Vol. 9; no. 1; pp. 529 - 5219 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
17.10.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple dose bioavailability study. Postmenopausal women (
n
= 38) consumed daily 250 mL of a beverage with or without 2 g of PS added during 6 weeks in each of the study periods. With the intake of the PS-added beverage, significant decreases (mg dL
−1
) in serum total cholesterol (pre-treatment: 220.0 ± 27.8
vs.
post-treatment: 212.9 ± 25.8;
p
< 0.05) and LDL-cholesterol (129.4 ± 28.5
vs.
121.7 ± 24.4;
p
< 0.05) were detected. The cholesterol precursor lathosterol (11.2%), markers of the dietary PS intake (campesterol 43.1% and β-sitosterol 32.5%), and anti-inflammatory IL-10 cytokine (22.5%) increased significantly, with a concomitant significant reduction in pro-inflammatory IL-1β (6.7%). No variations in HDL-cholesterol, other sterols (desmosterol and stigmasterol) or cytokines (IL-6, IL-8, IL-12p70 and TNF-α) were detected. These results indicated that this kind of PS-enriched milk-based fruit beverage is suitable during the period of clinical intervention, and its consumption may be an adequate way to improve PS functionality since a significant reduction in cholesterol levels has been observed. Therefore, the intake of this beverage could contribute to reduce the risk of cardiovascular disease also obtaining a beneficial effect on the serum inflammatory status in postmenopausal women.
Positive impact on serum lipids and cytokines after functional beverage's intake by postmenopausal women. |
|---|---|
| AbstractList | The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple dose bioavailability study. Postmenopausal women (
n
= 38) consumed daily 250 mL of a beverage with or without 2 g of PS added during 6 weeks in each of the study periods. With the intake of the PS-added beverage, significant decreases (mg dL
−1
) in serum total cholesterol (pre-treatment: 220.0 ± 27.8
vs.
post-treatment: 212.9 ± 25.8;
p
< 0.05) and LDL-cholesterol (129.4 ± 28.5
vs.
121.7 ± 24.4;
p
< 0.05) were detected. The cholesterol precursor lathosterol (11.2%), markers of the dietary PS intake (campesterol 43.1% and β-sitosterol 32.5%), and anti-inflammatory IL-10 cytokine (22.5%) increased significantly, with a concomitant significant reduction in pro-inflammatory IL-1β (6.7%). No variations in HDL-cholesterol, other sterols (desmosterol and stigmasterol) or cytokines (IL-6, IL-8, IL-12p70 and TNF-α) were detected. These results indicated that this kind of PS-enriched milk-based fruit beverage is suitable during the period of clinical intervention, and its consumption may be an adequate way to improve PS functionality since a significant reduction in cholesterol levels has been observed. Therefore, the intake of this beverage could contribute to reduce the risk of cardiovascular disease also obtaining a beneficial effect on the serum inflammatory status in postmenopausal women.
Positive impact on serum lipids and cytokines after functional beverage's intake by postmenopausal women. The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple dose bioavailability study. Postmenopausal women ( n = 38) consumed daily 250 mL of a beverage with or without 2 g of PS added during 6 weeks in each of the study periods. With the intake of the PS-added beverage, significant decreases (mg dL −1 ) in serum total cholesterol (pre-treatment: 220.0 ± 27.8 vs. post-treatment: 212.9 ± 25.8; p < 0.05) and LDL-cholesterol (129.4 ± 28.5 vs. 121.7 ± 24.4; p < 0.05) were detected. The cholesterol precursor lathosterol (11.2%), markers of the dietary PS intake (campesterol 43.1% and β-sitosterol 32.5%), and anti-inflammatory IL-10 cytokine (22.5%) increased significantly, with a concomitant significant reduction in pro-inflammatory IL-1β (6.7%). No variations in HDL-cholesterol, other sterols (desmosterol and stigmasterol) or cytokines (IL-6, IL-8, IL-12p70 and TNF-α) were detected. These results indicated that this kind of PS-enriched milk-based fruit beverage is suitable during the period of clinical intervention, and its consumption may be an adequate way to improve PS functionality since a significant reduction in cholesterol levels has been observed. Therefore, the intake of this beverage could contribute to reduce the risk of cardiovascular disease also obtaining a beneficial effect on the serum inflammatory status in postmenopausal women. The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple dose bioavailability study. Postmenopausal women (n = 38) consumed daily 250 mL of a beverage with or without 2 g of PS added during 6 weeks in each of the study periods. With the intake of the PS-added beverage, significant decreases (mg dL⁻¹) in serum total cholesterol (pre-treatment: 220.0 ± 27.8 vs. post-treatment: 212.9 ± 25.8; p < 0.05) and LDL-cholesterol (129.4 ± 28.5 vs. 121.7 ± 24.4; p < 0.05) were detected. The cholesterol precursor lathosterol (11.2%), markers of the dietary PS intake (campesterol 43.1% and β-sitosterol 32.5%), and anti-inflammatory IL-10 cytokine (22.5%) increased significantly, with a concomitant significant reduction in pro-inflammatory IL-1β (6.7%). No variations in HDL-cholesterol, other sterols (desmosterol and stigmasterol) or cytokines (IL-6, IL-8, IL-12p70 and TNF-α) were detected. These results indicated that this kind of PS-enriched milk-based fruit beverage is suitable during the period of clinical intervention, and its consumption may be an adequate way to improve PS functionality since a significant reduction in cholesterol levels has been observed. Therefore, the intake of this beverage could contribute to reduce the risk of cardiovascular disease also obtaining a beneficial effect on the serum inflammatory status in postmenopausal women. The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple dose bioavailability study. Postmenopausal women (n = 38) consumed daily 250 mL of a beverage with or without 2 g of PS added during 6 weeks in each of the study periods. With the intake of the PS-added beverage, significant decreases (mg dL-1) in serum total cholesterol (pre-treatment: 220.0 ± 27.8 vs. post-treatment: 212.9 ± 25.8; p < 0.05) and LDL-cholesterol (129.4 ± 28.5 vs. 121.7 ± 24.4; p < 0.05) were detected. The cholesterol precursor lathosterol (11.2%), markers of the dietary PS intake (campesterol 43.1% and β-sitosterol 32.5%), and anti-inflammatory IL-10 cytokine (22.5%) increased significantly, with a concomitant significant reduction in pro-inflammatory IL-1β (6.7%). No variations in HDL-cholesterol, other sterols (desmosterol and stigmasterol) or cytokines (IL-6, IL-8, IL-12p70 and TNF-α) were detected. These results indicated that this kind of PS-enriched milk-based fruit beverage is suitable during the period of clinical intervention, and its consumption may be an adequate way to improve PS functionality since a significant reduction in cholesterol levels has been observed. Therefore, the intake of this beverage could contribute to reduce the risk of cardiovascular disease also obtaining a beneficial effect on the serum inflammatory status in postmenopausal women.The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple dose bioavailability study. Postmenopausal women (n = 38) consumed daily 250 mL of a beverage with or without 2 g of PS added during 6 weeks in each of the study periods. With the intake of the PS-added beverage, significant decreases (mg dL-1) in serum total cholesterol (pre-treatment: 220.0 ± 27.8 vs. post-treatment: 212.9 ± 25.8; p < 0.05) and LDL-cholesterol (129.4 ± 28.5 vs. 121.7 ± 24.4; p < 0.05) were detected. The cholesterol precursor lathosterol (11.2%), markers of the dietary PS intake (campesterol 43.1% and β-sitosterol 32.5%), and anti-inflammatory IL-10 cytokine (22.5%) increased significantly, with a concomitant significant reduction in pro-inflammatory IL-1β (6.7%). No variations in HDL-cholesterol, other sterols (desmosterol and stigmasterol) or cytokines (IL-6, IL-8, IL-12p70 and TNF-α) were detected. These results indicated that this kind of PS-enriched milk-based fruit beverage is suitable during the period of clinical intervention, and its consumption may be an adequate way to improve PS functionality since a significant reduction in cholesterol levels has been observed. Therefore, the intake of this beverage could contribute to reduce the risk of cardiovascular disease also obtaining a beneficial effect on the serum inflammatory status in postmenopausal women. The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple dose bioavailability study. Postmenopausal women (n = 38) consumed daily 250 mL of a beverage with or without 2 g of PS added during 6 weeks in each of the study periods. With the intake of the PS-added beverage, significant decreases (mg dL-1) in serum total cholesterol (pre-treatment: 220.0 ± 27.8 vs. post-treatment: 212.9 ± 25.8; p < 0.05) and LDL-cholesterol (129.4 ± 28.5 vs. 121.7 ± 24.4; p < 0.05) were detected. The cholesterol precursor lathosterol (11.2%), markers of the dietary PS intake (campesterol 43.1% and β-sitosterol 32.5%), and anti-inflammatory IL-10 cytokine (22.5%) increased significantly, with a concomitant significant reduction in pro-inflammatory IL-1β (6.7%). No variations in HDL-cholesterol, other sterols (desmosterol and stigmasterol) or cytokines (IL-6, IL-8, IL-12p70 and TNF-α) were detected. These results indicated that this kind of PS-enriched milk-based fruit beverage is suitable during the period of clinical intervention, and its consumption may be an adequate way to improve PS functionality since a significant reduction in cholesterol levels has been observed. Therefore, the intake of this beverage could contribute to reduce the risk of cardiovascular disease also obtaining a beneficial effect on the serum inflammatory status in postmenopausal women. The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple dose bioavailability study. Postmenopausal women (n = 38) consumed daily 250 mL of a beverage with or without 2 g of PS added during 6 weeks in each of the study periods. With the intake of the PS-added beverage, significant decreases (mg dL−1) in serum total cholesterol (pre-treatment: 220.0 ± 27.8 vs. post-treatment: 212.9 ± 25.8; p < 0.05) and LDL-cholesterol (129.4 ± 28.5 vs. 121.7 ± 24.4; p < 0.05) were detected. The cholesterol precursor lathosterol (11.2%), markers of the dietary PS intake (campesterol 43.1% and β-sitosterol 32.5%), and anti-inflammatory IL-10 cytokine (22.5%) increased significantly, with a concomitant significant reduction in pro-inflammatory IL-1β (6.7%). No variations in HDL-cholesterol, other sterols (desmosterol and stigmasterol) or cytokines (IL-6, IL-8, IL-12p70 and TNF-α) were detected. These results indicated that this kind of PS-enriched milk-based fruit beverage is suitable during the period of clinical intervention, and its consumption may be an adequate way to improve PS functionality since a significant reduction in cholesterol levels has been observed. Therefore, the intake of this beverage could contribute to reduce the risk of cardiovascular disease also obtaining a beneficial effect on the serum inflammatory status in postmenopausal women. |
| Author | Blanco-Morales, Virginia Garcia-Llatas, Guadalupe Hernández-Álvarez, Elena Cilla, Antonio Silvestre, Ramona Ángeles Alvarez-Sala, Andrea Granado-Lorencio, Fernando Barberá, Reyes |
| AuthorAffiliation | Faculty of Pharmacy Nutrition and Food Science Area Clinical Biochemistry. Hospital Universitario Puerta de Hierro-Majadahonda University of Valencia Universidad Autónoma de Madrid |
| AuthorAffiliation_xml | – sequence: 0 name: Faculty of Pharmacy – sequence: 0 name: University of Valencia – sequence: 0 name: Universidad Autónoma de Madrid – sequence: 0 name: Nutrition and Food Science Area – sequence: 0 name: Clinical Biochemistry. Hospital Universitario Puerta de Hierro-Majadahonda |
| Author_xml | – sequence: 1 givenname: Andrea surname: Alvarez-Sala fullname: Alvarez-Sala, Andrea – sequence: 2 givenname: Virginia surname: Blanco-Morales fullname: Blanco-Morales, Virginia – sequence: 3 givenname: Antonio surname: Cilla fullname: Cilla, Antonio – sequence: 4 givenname: Ramona Ángeles surname: Silvestre fullname: Silvestre, Ramona Ángeles – sequence: 5 givenname: Elena surname: Hernández-Álvarez fullname: Hernández-Álvarez, Elena – sequence: 6 givenname: Fernando surname: Granado-Lorencio fullname: Granado-Lorencio, Fernando – sequence: 7 givenname: Reyes surname: Barberá fullname: Barberá, Reyes – sequence: 8 givenname: Guadalupe surname: Garcia-Llatas fullname: Garcia-Llatas, Guadalupe |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30206618$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.numecd.2014.04.013 10.1080/07315724.2013.816597 10.1186/1476-9255-7-54 10.1016/j.numecd.2013.03.003 10.3945/jn.108.095125 10.3945/ajcn.115.107045 10.1016/j.jff.2016.12.028 10.1016/j.chemphyslip.2003.09.015 10.1161/ATVBAHA.110.207415 10.1016/j.atherosclerosis.2013.08.012 10.1016/j.atherosclerosis.2013.11.043 10.1021/jf1044102 10.1093/clinchem/18.6.499 10.1016/j.steroids.2015.03.007 10.1111/j.1753-4887.2011.00399.x 10.1016/j.cytogfr.2015.04.003 10.1016/j.atherosclerosis.2016.01.035 10.1016/j.chemphyslip.2008.05.002 10.1016/S0021-9150(01)00562-7 10.2119/molmed.2010-00004 10.1093/ajcn/86.3.790 10.3945/ajcn.115.117531 10.1080/10715762.2016.1252839 10.1016/j.clnu.2011.03.009 10.1093/jn/135.10.2438 10.1007/s12170-013-0371-4 10.1038/sj.ejcn.1602362 10.1016/j.diabet.2014.11.006 10.1016/j.jfca.2017.03.011 10.1002/mnfr.201500586 10.1007/s00394-007-0693-4 10.1016/j.jff.2015.01.023 10.3109/13697137.2012.700743 10.1002/ejlt.201100331 10.1194/jlr.M300089-JLR200 10.1016/S1138-0322(10)70002-X 10.1016/j.chemphyslip.2011.06.005 10.1016/j.nutres.2006.08.006 10.3177/jnsv.35.361 10.1021/jf3002679 10.1016/j.numecd.2008.03.012 10.1016/j.chemphyslip.2011.10.004 10.1016/j.lfs.2006.10.006 10.1016/j.jff.2017.10.006 10.1021/acs.jafc.6b02028 10.3945/jn.108.103481 10.1038/sj.ejcn.1601837 10.1017/S0007114511005162 10.1155/2013/192325 10.1017/S0007114514000750 10.1016/j.jff.2014.12.001 |
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| References | Rueda (C8FO00353J-(cit25)/*[position()=1]) 2014; 8 Camilleri (C8FO00353J-(cit31)/*[position()=1]) 2012; 15 Mel'nikov (C8FO00353J-(cit40)/*[position()=1]) 2004; 127 Friedewald (C8FO00353J-(cit32)/*[position()=1]) 1972; 18 Ho (C8FO00353J-(cit10)/*[position()=1]) 2016; 50 Mannarino (C8FO00353J-(cit45)/*[position()=1]) 2009; 19 Yin (C8FO00353J-(cit52)/*[position()=1]) 2010; 16 Mensink (C8FO00353J-(cit8)/*[position()=1]) 2002; 160 Stapleton (C8FO00353J-(cit30)/*[position()=1]) 2010; 7 Cilla (C8FO00353J-(cit15)/*[position()=1]) 2015; 12 Alvarez-Sala (C8FO00353J-(cit29)/*[position()=1]) 2016; 64 Ait-Oufella (C8FO00353J-(cit18)/*[position()=1]) 2011; 31 Hallikainen (C8FO00353J-(cit12)/*[position()=1]) 2013 Clifton (C8FO00353J-(cit26)/*[position()=1]) 2004; 58 Conway (C8FO00353J-(cit27)/*[position()=1]) 2013; 23 Rosqvist (C8FO00353J-(cit28)/*[position()=1]) 2015; 102 Devaraj (C8FO00353J-(cit23)/*[position()=1]) 2011; 30 González-Larena (C8FO00353J-(cit34)/*[position()=1]) 2012; 60 Garcia-Llatas (C8FO00353J-(cit14)/*[position()=1]) 2015; 14 Jones (C8FO00353J-(cit11)/*[position()=1]) 2003; 44 Escurriol (C8FO00353J-(cit7)/*[position()=1]) 2010; 14 Ikeda (C8FO00353J-(cit37)/*[position()=1]) 1989; 35 Garcia-Llatas (C8FO00353J-(cit33)/*[position()=1]) 2012; 114 Alvarez-Sala (C8FO00353J-(cit35)/*[position()=1]) 2018; 68 Granado-Lorencio (C8FO00353J-(cit13)/*[position()=1]) 2014; 24 Demonty (C8FO00353J-(cit46)/*[position()=1]) 2009; 139 Plat (C8FO00353J-(cit22)/*[position()=1]) 2009; 139 Plana (C8FO00353J-(cit44)/*[position()=1]) 2008; 47 García-Llatas (C8FO00353J-(cit3)/*[position()=1]) 2011; 164 Matsuoka (C8FO00353J-(cit36)/*[position()=1]) 2012; 165 Santosa (C8FO00353J-(cit48)/*[position()=1]) 2007; 80 Ramji (C8FO00353J-(cit19)/*[position()=1]) 2015; 26 Rocha (C8FO00353J-(cit24)/*[position()=1]) 2016; 248 Gleize (C8FO00353J-(cit41)/*[position()=1]) 2016; 60 González-Larena (C8FO00353J-(cit47)/*[position()=1]) 2011; 59 Korpela (C8FO00353J-(cit42)/*[position()=1]) 2006; 60 Matsuoka (C8FO00353J-(cit39)/*[position()=1]) 2008; 154 Jesch (C8FO00353J-(cit38)/*[position()=1]) 2006; 26 Ras (C8FO00353J-(cit6)/*[position()=1]) 2013; 230 Othman (C8FO00353J-(cit20)/*[position()=1]) 2011; 69 Ras (C8FO00353J-(cit1)/*[position()=1]) 2014; 112 Brüll (C8FO00353J-(cit9)/*[position()=1]) 2016; 103 Casas-Agustench (C8FO00353J-(cit49)/*[position()=1]) 2012; 107 López-García (C8FO00353J-(cit16)/*[position()=1]) 2017; 39 Gylling (C8FO00353J-(cit2)/*[position()=1]) 2014; 232 Hansel (C8FO00353J-(cit43)/*[position()=1]) 2007; 86 Bard (C8FO00353J-(cit5)/*[position()=1]) 2015; 41 López-García (C8FO00353J-(cit17)/*[position()=1]) 2017; 30 Nashed (C8FO00353J-(cit51)/*[position()=1]) 2005; 135 Kunces (C8FO00353J-(cit21)/*[position()=1]) 2013; 32 Andrade (C8FO00353J-(cit50)/*[position()=1]) 2015; 99 |
| References_xml | – volume: 24 start-page: 1090 year: 2014 ident: C8FO00353J-(cit13)/*[position()=1] publication-title: Nutr., Metab. Cardiovasc. Dis. doi: 10.1016/j.numecd.2014.04.013 – volume: 32 start-page: 234 year: 2013 ident: C8FO00353J-(cit21)/*[position()=1] publication-title: J. Am. Coll. Nutr. doi: 10.1080/07315724.2013.816597 – volume: 7 start-page: 54 year: 2010 ident: C8FO00353J-(cit30)/*[position()=1] publication-title: J. Inflammation doi: 10.1186/1476-9255-7-54 – volume: 23 start-page: 1255 year: 2013 ident: C8FO00353J-(cit27)/*[position()=1] publication-title: Nutr., Metab. Cardiovasc. Dis. doi: 10.1016/j.numecd.2013.03.003 – volume: 139 start-page: 1 year: 2009 ident: C8FO00353J-(cit46)/*[position()=1] publication-title: J. Nutr. doi: 10.3945/jn.108.095125 – volume: 102 start-page: 20 year: 2015 ident: C8FO00353J-(cit28)/*[position()=1] publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.115.107045 – volume: 30 start-page: 81 year: 2017 ident: C8FO00353J-(cit17)/*[position()=1] publication-title: J. Funct. Foods doi: 10.1016/j.jff.2016.12.028 – volume: 127 start-page: 121 year: 2004 ident: C8FO00353J-(cit40)/*[position()=1] publication-title: Chem. Phys. Lipids doi: 10.1016/j.chemphyslip.2003.09.015 – volume: 31 start-page: 969 year: 2011 ident: C8FO00353J-(cit18)/*[position()=1] publication-title: Arterioscler., Thromb., Vasc. Biol. doi: 10.1161/ATVBAHA.110.207415 – volume: 230 start-page: 336 year: 2013 ident: C8FO00353J-(cit6)/*[position()=1] publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2013.08.012 – volume: 232 start-page: 346 year: 2014 ident: C8FO00353J-(cit2)/*[position()=1] publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2013.11.043 – volume: 59 start-page: 3624 year: 2011 ident: C8FO00353J-(cit47)/*[position()=1] publication-title: J. Agric. Food Chem. doi: 10.1021/jf1044102 – volume: 18 start-page: 499 year: 1972 ident: C8FO00353J-(cit32)/*[position()=1] publication-title: Clin. Chem. doi: 10.1093/clinchem/18.6.499 – volume: 99 start-page: 293 year: 2015 ident: C8FO00353J-(cit50)/*[position()=1] publication-title: Steroids doi: 10.1016/j.steroids.2015.03.007 – volume: 69 start-page: 371 year: 2011 ident: C8FO00353J-(cit20)/*[position()=1] publication-title: Nutr. Rev. doi: 10.1111/j.1753-4887.2011.00399.x – volume: 26 start-page: 673 year: 2015 ident: C8FO00353J-(cit19)/*[position()=1] publication-title: Cytokine Growth Factor Rev. doi: 10.1016/j.cytogfr.2015.04.003 – volume: 248 start-page: 76 year: 2016 ident: C8FO00353J-(cit24)/*[position()=1] publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2016.01.035 – volume: 154 start-page: 87 year: 2008 ident: C8FO00353J-(cit39)/*[position()=1] publication-title: Chem. Phys. Lipids doi: 10.1016/j.chemphyslip.2008.05.002 – volume: 160 start-page: 205 year: 2002 ident: C8FO00353J-(cit8)/*[position()=1] publication-title: Atherosclerosis doi: 10.1016/S0021-9150(01)00562-7 – volume: 16 start-page: 438 year: 2010 ident: C8FO00353J-(cit52)/*[position()=1] publication-title: Mol. Med. doi: 10.2119/molmed.2010-00004 – volume: 86 start-page: 790 year: 2007 ident: C8FO00353J-(cit43)/*[position()=1] publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/86.3.790 – volume: 103 start-page: 444 year: 2016 ident: C8FO00353J-(cit9)/*[position()=1] publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.115.117531 – volume: 50 start-page: 1396 year: 2016 ident: C8FO00353J-(cit10)/*[position()=1] publication-title: Free Radical Res. doi: 10.1080/10715762.2016.1252839 – volume: 30 start-page: 668 year: 2011 ident: C8FO00353J-(cit23)/*[position()=1] publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2011.03.009 – volume: 135 start-page: 2438 year: 2005 ident: C8FO00353J-(cit51)/*[position()=1] publication-title: J. Nutr. doi: 10.1093/jn/135.10.2438 – volume: 8 start-page: 371 year: 2014 ident: C8FO00353J-(cit25)/*[position()=1] publication-title: Curr. Cardiovasc. Risk Rep. doi: 10.1007/s12170-013-0371-4 – volume: 60 start-page: 633 year: 2006 ident: C8FO00353J-(cit42)/*[position()=1] publication-title: Eur. J. Clin. Nutr. doi: 10.1038/sj.ejcn.1602362 – volume: 41 start-page: 69 year: 2015 ident: C8FO00353J-(cit5)/*[position()=1] publication-title: Diabetes Metab. doi: 10.1016/j.diabet.2014.11.006 – volume: 68 start-page: 111 year: 2018 ident: C8FO00353J-(cit35)/*[position()=1] publication-title: J. Food Compos. Anal. doi: 10.1016/j.jfca.2017.03.011 – volume: 60 start-page: 749 year: 2016 ident: C8FO00353J-(cit41)/*[position()=1] publication-title: Mol. Nutr. Food Res. doi: 10.1002/mnfr.201500586 – volume: 47 start-page: 32 year: 2008 ident: C8FO00353J-(cit44)/*[position()=1] publication-title: Eur. J. Nutr. doi: 10.1007/s00394-007-0693-4 – volume: 14 start-page: 44 year: 2015 ident: C8FO00353J-(cit14)/*[position()=1] publication-title: J. Funct. Foods doi: 10.1016/j.jff.2015.01.023 – volume: 15 start-page: 524 year: 2012 ident: C8FO00353J-(cit31)/*[position()=1] publication-title: Climacteric doi: 10.3109/13697137.2012.700743 – volume: 114 start-page: 520 year: 2012 ident: C8FO00353J-(cit33)/*[position()=1] publication-title: Eur. J. Lipid Sci. Technol. doi: 10.1002/ejlt.201100331 – volume: 44 start-page: 1713 year: 2003 ident: C8FO00353J-(cit11)/*[position()=1] publication-title: J. Lipid Res. doi: 10.1194/jlr.M300089-JLR200 – volume: 14 start-page: 3 year: 2010 ident: C8FO00353J-(cit7)/*[position()=1] publication-title: Actividad Dietética doi: 10.1016/S1138-0322(10)70002-X – volume: 164 start-page: 607 year: 2011 ident: C8FO00353J-(cit3)/*[position()=1] publication-title: Chem. Phys. Lipids doi: 10.1016/j.chemphyslip.2011.06.005 – volume: 26 start-page: 579 year: 2006 ident: C8FO00353J-(cit38)/*[position()=1] publication-title: Nutr. Res. doi: 10.1016/j.nutres.2006.08.006 – volume: 35 start-page: 361 year: 1989 ident: C8FO00353J-(cit37)/*[position()=1] publication-title: J. Nutr. Sci. Vitaminol. doi: 10.3177/jnsv.35.361 – volume: 60 start-page: 4725 year: 2012 ident: C8FO00353J-(cit34)/*[position()=1] publication-title: J. Agric. Food Chem. doi: 10.1021/jf3002679 – volume: 19 start-page: 84 year: 2009 ident: C8FO00353J-(cit45)/*[position()=1] publication-title: Nutr., Metab. Cardiovasc. Dis. doi: 10.1016/j.numecd.2008.03.012 – volume: 165 start-page: 7 year: 2012 ident: C8FO00353J-(cit36)/*[position()=1] publication-title: Chem. Phys. Lipids doi: 10.1016/j.chemphyslip.2011.10.004 – volume: 80 start-page: 505 year: 2007 ident: C8FO00353J-(cit48)/*[position()=1] publication-title: Life Sci. doi: 10.1016/j.lfs.2006.10.006 – volume: 39 start-page: 84 year: 2017 ident: C8FO00353J-(cit16)/*[position()=1] publication-title: J. Funct. Foods doi: 10.1016/j.jff.2017.10.006 – volume: 64 start-page: 5686 year: 2016 ident: C8FO00353J-(cit29)/*[position()=1] publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.6b02028 – volume: 139 start-page: 1143 year: 2009 ident: C8FO00353J-(cit22)/*[position()=1] publication-title: J. Nutr. doi: 10.3945/jn.108.103481 – volume: 58 start-page: 503 year: 2004 ident: C8FO00353J-(cit26)/*[position()=1] publication-title: Eur. J. Clin. Nutr. doi: 10.1038/sj.ejcn.1601837 – volume: 107 start-page: 1766 year: 2012 ident: C8FO00353J-(cit49)/*[position()=1] publication-title: Br. J. Nutr. doi: 10.1017/S0007114511005162 – start-page: 192325 year: 2013 ident: C8FO00353J-(cit12)/*[position()=1] publication-title: Cholesterol doi: 10.1155/2013/192325 – volume: 112 start-page: 214 year: 2014 ident: C8FO00353J-(cit1)/*[position()=1] publication-title: Br. J. Nutr. doi: 10.1017/S0007114514000750 – volume: 12 start-page: 282 year: 2015 ident: C8FO00353J-(cit15)/*[position()=1] publication-title: J. Funct. Foods doi: 10.1016/j.jff.2014.12.001 |
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| SubjectTerms | Anticholesteremic Agents - analysis Anticholesteremic Agents - metabolism beta-sitosterol Beverages Beverages - analysis Bioavailability Biomarkers blood lipids blood serum campesterol Cardiovascular diseases cholesteremic effect Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Clinical trials Consumption Crossovers Cytokines Cytokines - genetics Cytokines - metabolism Dietary intake Double-Blind Method Female Fruits Glycolipids - metabolism Glycoproteins - metabolism Health risks High density lipoprotein high density lipoprotein cholesterol Humans Hypercholesterolemia - blood Hypercholesterolemia - diet therapy IL-1β Inflammation Interleukin 10 Interleukin 12 Interleukin 6 Interleukin 8 interleukin-1beta lipid composition Lipids Lipids - blood Low density lipoprotein low density lipoprotein cholesterol Middle Aged Milk milk fat Milk fat globule membranes Phytosterols - metabolism Post-menopause postmenopause Postmenopause - metabolism Precursors Pretreatment Reduction risk reduction Sterols stigmasterol tumor necrosis factor-alpha Tumor necrosis factor-α women |
| Title | A positive impact on the serum lipid profile and cytokines after the consumption of a plant sterol-enriched beverage with a milk fat globule membrane: a clinical study |
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