The Salmonella Typhimurium Effector SpvB Subverts Host Membrane Trafficking by Targeting Clathrin and AP-1

• Published in: Molecular & cellular proteomics Vol. 22; no. 12; p. 100674
• Main Authors: Yuan, Yi, Wang, Xinghao, Jin, Jie, Tang, Zhiheng, Xian, Wei, Zhang, Xinyi, Fu, Jiaqi, He, Kangmin, Liu, Xiaoyun
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 01.12.2023
• Subjects: Actins - metabolism; Clathrin - metabolism; Salmonella enterica - metabolism; Salmonella typhimurium - metabolism; Transcription Factor AP-1 - metabolism; Virulence Factors - metabolism; clathrin; AP-1; SpvB; membrane trafficking; Salmonella Typhimurium

Salmonella enterica, the etiological agent of gastrointestinal and systemic diseases, translocates a plethora of virulence factors through its type III secretion systems to host cells during infection. Among them, SpvB has been reported to harbor an ADP-ribosyltransferase domain in its C terminus, w...