Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes

• Published in: Theranostics Vol. 9; no. 25; pp. 7490 - 7505
• Main Authors: Cao, Qiuhua, Gao, Xinghua, Lin, Yanting, Yue, Chongxiu, Wang, Yue, Quan, Fei, Zhang, Zixuan, Liu, Xiaoxuan, Lu, Yuan, Zhan, Yanling, Yang, Hongbao, Li, Xianjing, Qin, Di, Birnbaumer, Lutz, Hao, Kun, Yang, Yong
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2019; Ivyspring International Publisher
• Subjects: Adaptive Immunity - drug effects; Animals; Atrophy; Biological activity; Blood; Cell Line, Tumor; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - drug therapy; Colitis, Ulcerative - metabolism; Colon; Colon - drug effects; Colon - metabolism; Dextran Sulfate - pharmacology; Disease; Disease Models, Animal; Drugs; Feces - microbiology; Gastrointestinal Microbiome - drug effects; HCT116 Cells; Humans; Immune system; Immunity, Innate - drug effects; Inflammatory bowel disease; Interleukin-22; Interleukins - metabolism; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Lymphocytes; Lymphocytes - drug effects; Lymphocytes - metabolism; Male; Mice; Mice, Inbred C57BL; Pathology; Research Paper; Sodium; Spleen - drug effects; Spleen - metabolism; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - metabolism; Thymopentin - pharmacology; Thymus gland; DSS-induced colitis; thymopentin; lymphocytes; IL-22; gut microbiota

Ulcerative colitis (UC) is a chronic inflammatory gastrointestinal disease, notoriously challenging to treat. Previous studies have found a positive correlation between thymic atrophy and colitis severity. It was, therefore, worthwhile to investigate the effect of thymopentin (TP5), a synthetic pent...