Sensitivity and reliability of zinc transporter and metallothionein gene expression in peripheral blood mononuclear cells as indicators of zinc status: responses to ex vivo zinc exposure and habitual zinc intake in humans

• Published in: British journal of nutrition Vol. 125; no. 4; pp. 361 - 368
• Main Authors: Hennigar, Stephen R., Kelley, Alyssa M., Anderson, Bradley J., Armstrong, Nicholes J., McClung, Holly L., Berryman, Claire E., Karl, J. Philip, McClung, James P.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.02.2021
• Subjects: Biomarkers; Blood; Blood & organ donations; Data analysis; Dietary intake; Ethylenediamine; ethylenediamines; females; Food; Gene expression; humans; Isoforms; Leukocytes (mononuclear); males; Metallothionein; Molecular Nutrition; Nutrient status; nutrition; Nutrition research; Peripheral blood mononuclear cells; Plasma; Proteins; Reliability; Sensitivity; Transcription factors; Zinc; Zinc sulfate; Zinc transporter; United States > US; Biomarkers; Leucocytes; Metallothionein; Zinc transporter

Zn is an essential nutrient for humans; however, a sensitive biomarker to assess Zn status has not been identified. The objective of this study was to determine the reliability and sensitivity of Zn transporter and metallothionein (MT) genes in peripheral blood mononuclear cells (PBMCs) to Zn exposu...