Organoid Transplantation Can Improve Reproductive Prognosis by Promoting Endometrial Repair in Mice
Intrauterine adhesion (IUA) is one of the major causes of refractory secondary infertility, especially in regions and countries with high abortion rates. In this study, we used the mouse IUA model to evaluate the feasibility of the organoids, a 3D cell structure derived from endometrial tissue, as g...
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| Published in | International journal of biological sciences Vol. 18; no. 6; pp. 2627 - 2638 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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01.01.2022
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| Abstract | Intrauterine adhesion (IUA) is one of the major causes of refractory secondary infertility, especially in regions and countries with high abortion rates. In this study, we used the mouse IUA model to evaluate the feasibility of the organoids, a 3D cell structure derived from endometrial tissue, as grafts for the treatment of post-traumatic endometrial regeneration disorders.
The isolated and cultured endometrial organoid was transplanted into the model IUA uterus by the hydrogel scaffold method.
The cultured endometrial organoids were transplanted into the basal layer of the damaged endometrium for 28 days. They were completely implanted and grew normally. They not only reconstructed the structural integrity of the endometrial epithelium but also realized the functional repair of the endometrium through differentiation cultures and secretory functions.
For severe IUA, this method may be better than stem cell transplantation. These findings provide useful insights into the use of endometrial organoid regeneration in the treatment of injury repair. |
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| AbstractList | Intrauterine adhesion (IUA) is one of the major causes of refractory secondary infertility, especially in regions and countries with high abortion rates. In this study, we used the mouse IUA model to evaluate the feasibility of the organoids, a 3D cell structure derived from endometrial tissue, as grafts for the treatment of post-traumatic endometrial regeneration disorders.
The isolated and cultured endometrial organoid was transplanted into the model IUA uterus by the hydrogel scaffold method.
The cultured endometrial organoids were transplanted into the basal layer of the damaged endometrium for 28 days. They were completely implanted and grew normally. They not only reconstructed the structural integrity of the endometrial epithelium but also realized the functional repair of the endometrium through differentiation cultures and secretory functions.
For severe IUA, this method may be better than stem cell transplantation. These findings provide useful insights into the use of endometrial organoid regeneration in the treatment of injury repair. OBJECTIVEIntrauterine adhesion (IUA) is one of the major causes of refractory secondary infertility, especially in regions and countries with high abortion rates. In this study, we used the mouse IUA model to evaluate the feasibility of the organoids, a 3D cell structure derived from endometrial tissue, as grafts for the treatment of post-traumatic endometrial regeneration disorders. METHODSThe isolated and cultured endometrial organoid was transplanted into the model IUA uterus by the hydrogel scaffold method. RESULTSThe cultured endometrial organoids were transplanted into the basal layer of the damaged endometrium for 28 days. They were completely implanted and grew normally. They not only reconstructed the structural integrity of the endometrial epithelium but also realized the functional repair of the endometrium through differentiation cultures and secretory functions. CONCLUSIONFor severe IUA, this method may be better than stem cell transplantation. These findings provide useful insights into the use of endometrial organoid regeneration in the treatment of injury repair. Objective: Intrauterine adhesion (IUA) is one of the major causes of refractory secondary infertility, especially in regions and countries with high abortion rates. In this study, we used the mouse IUA model to evaluate the feasibility of the organoids, a 3D cell structure derived from endometrial tissue, as grafts for the treatment of post-traumatic endometrial regeneration disorders. Methods: The isolated and cultured endometrial organoid was transplanted into the model IUA uterus by the hydrogel scaffold method. Results: The cultured endometrial organoids were transplanted into the basal layer of the damaged endometrium for 28 days. They were completely implanted and grew normally. They not only reconstructed the structural integrity of the endometrial epithelium but also realized the functional repair of the endometrium through differentiation cultures and secretory functions. Conclusion: For severe IUA, this method may be better than stem cell transplantation. These findings provide useful insights into the use of endometrial organoid regeneration in the treatment of injury repair. |
| Author | Zhang, Huixing Lan, Jianqiang Hu, Mingyue Li, Gang Li, Yan Yuan, Juanjuan Zhu, Yu Xu, Dabao Jin, He Cao, Jia Liu, Dan |
| AuthorAffiliation | 2 College of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China 3 Nanfang Hospital, Southern Medical University, Guangzhou, China 6 Department of Gynecology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China 4 Key Laboratory of Ministry of Education for Fertility Preservation and Maintenance, Ningxia Medical University, Yinchuan, Ningxia, China 1 Department of Gynecology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China 5 Guangdong Research Center of Organoid Engineering and Technology, Guangzhou, Guangdong, China |
| AuthorAffiliation_xml | – name: 3 Nanfang Hospital, Southern Medical University, Guangzhou, China – name: 1 Department of Gynecology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China – name: 6 Department of Gynecology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China – name: 2 College of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China – name: 5 Guangdong Research Center of Organoid Engineering and Technology, Guangzhou, Guangdong, China – name: 4 Key Laboratory of Ministry of Education for Fertility Preservation and Maintenance, Ningxia Medical University, Yinchuan, Ningxia, China |
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| Keywords | Endometrial organoids ansplantation Endometrial regeneration Intrauterine adhesion (IUA) Three-dimensional culture |
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| Snippet | Intrauterine adhesion (IUA) is one of the major causes of refractory secondary infertility, especially in regions and countries with high abortion rates. In... Objective: Intrauterine adhesion (IUA) is one of the major causes of refractory secondary infertility, especially in regions and countries with high abortion... OBJECTIVEIntrauterine adhesion (IUA) is one of the major causes of refractory secondary infertility, especially in regions and countries with high abortion... |
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| SubjectTerms | Abdomen Abortion Animals Cell Differentiation Cytology Disease Models, Animal Endometrium Epithelium Estrogens Female Functionals Hormones Hydrogels Infertility Laboratory animals Medical prognosis Mice Organoids Pregnancy Regeneration Research Paper Stem cell transplantation Stem cells Structural integrity Tissue Adhesions - pathology Tissue Adhesions - therapy Tissue engineering Transplantation Ultrasonic imaging Uterine Diseases - pathology Uterine Diseases - therapy Uterus |
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| Title | Organoid Transplantation Can Improve Reproductive Prognosis by Promoting Endometrial Repair in Mice |
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