Bax- or Bak-Induced Mitochondrial Fission Can Be Uncoupled from Cytochrome c Release

• Published in: Molecular cell Vol. 31; no. 4; pp. 570 - 585
• Main Authors: Sheridan, Clare, Delivani, Petrina, Cullen, Sean P., Martin, Seamus J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.08.2008
• Subjects: Apoptosis; Apoptosis Regulatory Proteins - metabolism; bcl-2 Homologous Antagonist-Killer Protein - metabolism; bcl-2-Associated X Protein - metabolism; Bcl-2-Like Protein 11; bcl-X Protein - metabolism; BH3 Interacting Domain Death Agonist Protein - metabolism; Cell Line; CELLCYCLE; Cytochromes c - secretion; Humans; Membrane Proteins - metabolism; Mitochondria - metabolism; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-bcl-2 - metabolism; CELLCYCLE

Bax and Bak promote apoptosis by perturbing the permeability of the mitochondrial outer membrane and facilitating the release of cytochrome c by a mechanism that is still poorly defined. During apoptosis, Bax and Bak also promote fragmentation of the mitochondrial network, possibly by activating the...