Sustained release of alginate hydrogel containing antimicrobial peptide Chol-37(F34-R) in vitro and its effect on wound healing in murine model of Pseudomonas aeruginosa infection

• Published in: Journal of veterinary science (Suwŏn-si, Korea) Vol. 24; no. 3; pp. 101 - 117
• Main Authors: Shi, Shuaibing, Dong, Hefan, Chen, Xiaoyou, Xu, Siqi, Song, Yue, Li, Meiting, Yan, Zhiling, Wang, Xiaoli, Niu, Mingfu, Zhang, Min, Liao, Chengshui
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한수의학회 01.05.2023; The Korean Society of Veterinary Science
• Subjects: Alginates - chemistry; Alginates - pharmacology; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Bacteria; Cross-Sectional Studies; Delayed-Action Preparations; Disease Models, Animal; Hydrogels - chemistry; Hydrogels - pharmacology; Mice; Original; Pseudomonas Infections - drug therapy; Pseudomonas Infections - veterinary; Wound Healing; Cathelicidin; trauma; skin; dressings; antibacterial agent

Antibiotic resistance is a significant public health concern around the globe. Antimicrobial peptides exhibit broad-spectrum and efficient antibacterial activity with an added advantage of low drug resistance. The higher water content and 3D network structure of the hydrogels are beneficial for main...