Age and neuroinflammation: a lifetime of psychoneuroimmune consequences

• Published in: Immunology and allergy clinics of North America Vol. 29; no. 2; p. 321
• Main Authors: Godbout, Jonathan P, Johnson, Rodney W
• Format: Journal Article
• Language: English
• Published: United States 01.05.2009
• Subjects: Affect; Aging - immunology; Cytokines - physiology; Humans; Inflammation Mediators - physiology; Psychoneuroimmunology

Aging can impair functional interaction that occurs between the brain and the immune system. Recent findings indicate that microglia and astrocytes, innate immune cells of the brain, become more reactive during normal aging. This age-associated increase in innate immune reactivity sets the stage for...