Age and neuroinflammation: a lifetime of psychoneuroimmune consequences
Aging can impair functional interaction that occurs between the brain and the immune system. Recent findings indicate that microglia and astrocytes, innate immune cells of the brain, become more reactive during normal aging. This age-associated increase in innate immune reactivity sets the stage for...
Saved in:
| Published in | Immunology and allergy clinics of North America Vol. 29; no. 2; p. 321 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.05.2009
|
| Subjects | |
| Online Access | Get more information |
Cover
Loading…
| Abstract | Aging can impair functional interaction that occurs between the brain and the immune system. Recent findings indicate that microglia and astrocytes, innate immune cells of the brain, become more reactive during normal aging. This age-associated increase in innate immune reactivity sets the stage for an exaggerated inflammatory cytokine response in the brain after activation of the peripheral innate immune system. This elevated neuroinflammatory response may lead to more severe long-lasting behavioral and cognitive deficits. This article discusses new evidence that aging creates a brain environment that is permissive to the occurrence of mental health complications following innate immune activation. |
|---|---|
| AbstractList | Aging can impair functional interaction that occurs between the brain and the immune system. Recent findings indicate that microglia and astrocytes, innate immune cells of the brain, become more reactive during normal aging. This age-associated increase in innate immune reactivity sets the stage for an exaggerated inflammatory cytokine response in the brain after activation of the peripheral innate immune system. This elevated neuroinflammatory response may lead to more severe long-lasting behavioral and cognitive deficits. This article discusses new evidence that aging creates a brain environment that is permissive to the occurrence of mental health complications following innate immune activation. |
| Author | Johnson, Rodney W Godbout, Jonathan P |
| Author_xml | – sequence: 1 givenname: Jonathan P surname: Godbout fullname: Godbout, Jonathan P email: godbout.2@osu.edu organization: Institute for Behavioral Medicine Research, the Ohio State University, Columbus, OH 43210, USA. godbout.2@osu.edu – sequence: 2 givenname: Rodney W surname: Johnson fullname: Johnson, Rodney W |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19389585$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j71OwzAURi0Eoj_wACzIL5BwndbONVtV0YJUiQXmynWuwVVshzgZ-vZUKiznW44-6czYdUyRGHsQUAoQ6ulYemPLCkCXUJUA9RWbCinrAhXUEzbL-QggJKC8ZROhF6glyinbrr6Im9jwSGOffHStCcEMPsVnbnjrHQ0-EE-Od_lkv9NFC2GMxG2KmX5GipbyHbtxps10_7dz9rl5-Vi_Frv37dt6tSvsEtRQKGykRTqgNuYMqh0hSrC1qJqlFiSsVbIBg4Ag9dlwC1QNaiEskCZdzdnj5bcbD4Gafdf7YPrT_r-o-gXf5U8O |
| CitedBy_id | crossref_primary_10_3390_toxins7104199 crossref_primary_10_1016_j_jopan_2020_12_006 crossref_primary_10_1289_EHP9018 crossref_primary_10_1016_j_bbi_2011_06_015 crossref_primary_10_3389_fnagi_2022_1007629 crossref_primary_10_1139_apnm_2021_0133 crossref_primary_10_1016_j_exger_2019_05_005 crossref_primary_10_3390_physiologia4010007 crossref_primary_10_3389_fnins_2022_1006031 crossref_primary_10_1515_revneuro_2023_0047 crossref_primary_10_3389_fpsyt_2019_00030 crossref_primary_10_1111_j_1365_2990_2012_01306_x crossref_primary_10_3389_fphar_2021_806417 crossref_primary_10_1016_j_neurobiolaging_2013_02_010 crossref_primary_10_1080_15287394_2017_1286898 crossref_primary_10_1016_j_bbi_2013_04_004 crossref_primary_10_1016_j_jns_2017_08_013 crossref_primary_10_3389_fnagi_2021_788055 crossref_primary_10_1097_JGP_0b013e31825d08d6 crossref_primary_10_1515_revneuro_2017_0008 crossref_primary_10_1007_s12031_013_0092_7 crossref_primary_10_1016_j_bbi_2011_10_008 crossref_primary_10_1007_s10571_021_01069_4 crossref_primary_10_3390_brainsci14010041 crossref_primary_10_1016_j_jnutbio_2019_05_002 crossref_primary_10_1016_j_arr_2016_11_003 crossref_primary_10_1371_journal_pone_0052728 crossref_primary_10_3390_ijms19092615 crossref_primary_10_1007_s11481_011_9340_1 crossref_primary_10_1007_s12640_012_9334_7 crossref_primary_10_1016_j_bbi_2011_10_003 crossref_primary_10_1016_j_neuroscience_2013_02_019 crossref_primary_10_1186_s40303_016_0018_8 crossref_primary_10_1016_j_neulet_2014_04_043 crossref_primary_10_1016_j_pjnns_2016_10_004 crossref_primary_10_1016_j_exger_2018_07_023 crossref_primary_10_1016_j_exger_2015_11_004 crossref_primary_10_3892_ijmm_2013_1486 crossref_primary_10_1016_j_arr_2009_10_008 crossref_primary_10_1016_j_jneuroim_2018_09_002 crossref_primary_10_1016_j_yhbeh_2013_02_017 crossref_primary_10_1016_j_bbi_2015_06_005 crossref_primary_10_1097_ALN_0000000000000697 crossref_primary_10_1194_jlr_RA119000479 crossref_primary_10_3389_fnins_2021_632216 crossref_primary_10_1111_acel_14192 crossref_primary_10_1016_j_brainres_2009_12_091 crossref_primary_10_1016_j_archger_2018_03_011 crossref_primary_10_1016_j_jad_2022_05_019 crossref_primary_10_1016_S1474_4422_15_70016_5 crossref_primary_10_1096_fj_201700495R crossref_primary_10_1016_j_nlm_2016_05_011 crossref_primary_10_1111_j_1755_5949_2010_00173_x crossref_primary_10_1159_000356538 crossref_primary_10_1186_1742_2094_10_61 crossref_primary_10_1016_j_jagp_2013_09_005 crossref_primary_10_1002_gps_4823 crossref_primary_10_1007_s12035_015_9319_7 crossref_primary_10_1186_1742_2094_9_146 crossref_primary_10_1016_j_bbi_2015_09_003 crossref_primary_10_1016_j_bbi_2013_10_019 crossref_primary_10_1016_j_biopsych_2013_10_014 crossref_primary_10_1016_j_pharmthera_2011_01_014 crossref_primary_10_1016_j_nbd_2009_11_015 crossref_primary_10_1016_j_pbb_2020_172859 crossref_primary_10_1038_gt_2010_2 crossref_primary_10_1007_s12035_021_02606_4 crossref_primary_10_1111_ejn_12951 crossref_primary_10_1016_j_yfrne_2012_08_006 crossref_primary_10_3389_fnins_2014_00315 crossref_primary_10_1007_s11481_011_9313_4 crossref_primary_10_1016_j_bbi_2013_01_002 crossref_primary_10_3389_fnagi_2021_666181 crossref_primary_10_3389_fragi_2022_1014675 crossref_primary_10_1111_jnc_13667 crossref_primary_10_1089_rej_2011_1185 crossref_primary_10_1002_mds_27874 crossref_primary_10_1007_s11064_021_03498_5 crossref_primary_10_3390_jcm10132773 crossref_primary_10_1016_j_neurobiolaging_2015_01_012 crossref_primary_10_3390_antiox13040433 crossref_primary_10_3389_fnins_2015_00372 crossref_primary_10_1016_j_neurobiolaging_2014_01_018 crossref_primary_10_1177_09603271211061497 crossref_primary_10_1038_npp_2016_199 crossref_primary_10_1016_j_npbr_2013_04_004 crossref_primary_10_1007_s11064_012_0884_0 crossref_primary_10_1159_000485565 crossref_primary_10_3390_molecules27134124 crossref_primary_10_4162_nrp_2020_14_3_188 crossref_primary_10_1097_MD_0000000000022884 crossref_primary_10_1007_s11357_019_00070_6 crossref_primary_10_3390_brainsci14050497 crossref_primary_10_1523_JNEUROSCI_3688_11_2011 crossref_primary_10_1007_s11481_011_9299_y crossref_primary_10_1002_glia_22654 crossref_primary_10_3390_jcm13030806 crossref_primary_10_1007_s40011_015_0585_y crossref_primary_10_1016_j_neurobiolaging_2020_12_012 crossref_primary_10_1111_jcmm_12854 crossref_primary_10_1007_s11062_013_9368_3 crossref_primary_10_1016_j_neurobiolaging_2010_05_012 crossref_primary_10_4103_1673_5374_219047 crossref_primary_10_1111_j_1460_9568_2010_07296_x crossref_primary_10_1038_tp_2013_119 crossref_primary_10_22363_2313_0245_2023_27_3_285_292 crossref_primary_10_1016_j_pnpbp_2010_07_027 crossref_primary_10_1016_j_mehy_2011_06_019 crossref_primary_10_1016_j_nlm_2010_04_001 crossref_primary_10_1016_j_yfrne_2017_12_001 crossref_primary_10_1016_j_exger_2018_06_025 crossref_primary_10_1016_j_schres_2022_12_009 crossref_primary_10_1186_1471_2202_13_23 crossref_primary_10_1161_CIRCRESAHA_121_319877 crossref_primary_10_1089_rej_2011_1155 crossref_primary_10_1016_j_brainres_2016_07_045 crossref_primary_10_1038_srep37486 crossref_primary_10_1089_rej_2012_1405 crossref_primary_10_1111_j_1460_9568_2011_07738_x crossref_primary_10_1556_2060_2021_00186 crossref_primary_10_1111_j_1365_2990_2012_01307_x crossref_primary_10_3389_fpsyt_2021_761761 crossref_primary_10_1016_j_biopsych_2010_12_006 crossref_primary_10_1016_j_ejphar_2017_07_029 crossref_primary_10_1097_01_EHX_0000481739_67440_8f crossref_primary_10_1186_s12993_016_0111_2 crossref_primary_10_3390_ijms20071632 crossref_primary_10_3389_fnagi_2014_00171 crossref_primary_10_1007_s00018_012_0938_0 crossref_primary_10_1016_j_yhbeh_2012_02_021 crossref_primary_10_1016_j_brainresbull_2022_04_013 crossref_primary_10_1093_jnen_nlw117 crossref_primary_10_3390_brainsci13030500 crossref_primary_10_1093_schbul_sby024 crossref_primary_10_1186_s12974_019_1398_3 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1016/j.iac.2009.02.007 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1557-8607 |
| ExternalDocumentID | 19389585 |
| Genre | Journal Article Review |
| GroupedDBID | --- .1- .FO .GJ 0R~ 1P~ 34G 39C 4.4 457 53G 5GY 5RE AAEDT AAEDW AALRI AAQQT AAQXK AAWTL AAXUO ABCQX ABFRF ABJNI ABMAC ABQZK ACGFO ACGFS ADBBV ADMUD AEFWE AENEX AEVXI AFCTW AFRHN AFTJW AI. AJUYK ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AXIYT AZFZN B08 CGR COIAO CS3 CUY CVF DAHGL DU5 EBS ECM EIF EJD EX3 F5P FDB FEDTE FGOYB HVGLF HZ~ J5H L7B NPM O9- O9~ OK0 R2- RIG SEL SES UNMZH VH1 WOW Z5R ZGI |
| ID | FETCH-LOGICAL-c406t-68d5c8eb89aab89e7fe8850c712d491e1cc65d0a808059b89f386d8911c0e9e92 |
| IngestDate | Sat Sep 28 07:44:30 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c406t-68d5c8eb89aab89e7fe8850c712d491e1cc65d0a808059b89f386d8911c0e9e92 |
| PMID | 19389585 |
| ParticipantIDs | pubmed_primary_19389585 |
| PublicationCentury | 2000 |
| PublicationDate | 2009-05-01 |
| PublicationDateYYYYMMDD | 2009-05-01 |
| PublicationDate_xml | – month: 05 year: 2009 text: 2009-05-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Immunology and allergy clinics of North America |
| PublicationTitleAlternate | Immunol Allergy Clin North Am |
| PublicationYear | 2009 |
| SSID | ssj0015085 |
| Score | 2.3076668 |
| SecondaryResourceType | review_article |
| Snippet | Aging can impair functional interaction that occurs between the brain and the immune system. Recent findings indicate that microglia and astrocytes, innate... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 321 |
| SubjectTerms | Affect Aging - immunology Cytokines - physiology Humans Inflammation Mediators - physiology Psychoneuroimmunology |
| Title | Age and neuroinflammation: a lifetime of psychoneuroimmune consequences |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/19389585 |
| Volume | 29 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LTwIxEG5AE-PF-H6bHryZJSy77bbeiFHRBE8QOUm6fRiMPA548dc7bfclqFEvDWnLQvrNTqfTb2YQOk9SlaoklAEXigYxt-8cbDxBok1okhT0n0O6-0A7_fh-QAa12lOFtfQ2Txvy_cu4kv-gCn2Aq42S_QOyxUOhAz4DvtACwtD-CuP2s3f-u6SU8EBAd1ywNcTF68hoWzu-YDVP_UQbEuJI6gWPumqi3tnhMjOTrbViowN9CKUjfny66ykIPFNlOc5Vj3wZO5bV4fJUbjUBPfT4yd3AS3JfQ2cqksC-Rn2t2lyHZl6LUeUo6xVi5OOflxS19xm8NEZCZklDbeLUpDoXlmo2dsiBkck48aV9fh5dyJ2dD9VRHSwhWxbV-nKyOyYwTUl-z-0Yfwv_xeWT9d9fOHM426O3iTayQwNuewnYQjU92UZr3YwWsYNuQRAwgIWXBOESC5yLAZ4avCQGuCoGu6h_c9276gRZhYxAgiE2DyhTRDKdMi4ENDoxmjHSlEnYUjEPdSglJaopbPJQwmGGiRhVDDY42dRc89YeWpnAjx4grBWo9zSmkYzhEBsZRqig0Ck0WIGRMYdo3y_BcObToAzzxTn6duQYrZcidIJWDbx3-hSMuHl65rD4ACXhSLs |
| link.rule.ids | 782 |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Age+and+neuroinflammation%3A+a+lifetime+of+psychoneuroimmune+consequences&rft.jtitle=Immunology+and+allergy+clinics+of+North+America&rft.au=Godbout%2C+Jonathan+P&rft.au=Johnson%2C+Rodney+W&rft.date=2009-05-01&rft.eissn=1557-8607&rft.volume=29&rft.issue=2&rft.spage=321&rft_id=info:doi/10.1016%2Fj.iac.2009.02.007&rft_id=info%3Apmid%2F19389585&rft_id=info%3Apmid%2F19389585&rft.externalDocID=19389585 |