Metabolic bioenergy homeostatic disruption: a cause of anorexia nervosa
We believe anorexia nervosa is the result of a disruption in bioenergy homeostasis induced by lipid dysregulation. This disruption has two major determinants: (1) a biological predisposition to primary multihormonal disharmony linked to post-pubertal growth and development; and (2) an acquired abnor...
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| Published in | Medical hypotheses Vol. 56; no. 4; pp. 454 - 461 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Ltd
01.04.2001
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| Subjects | |
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| Abstract | We believe anorexia nervosa is the result of a disruption in bioenergy homeostasis induced by lipid dysregulation. This disruption has two major determinants: (1) a biological predisposition to primary multihormonal disharmony linked to post-pubertal growth and development; and (2) an acquired abnormal lipid-induced loop operation precipitated by inappropriate diet. We present a step-by-step model describing the cascade of disorders that culminates in anorexia nervosa: defective digestion and absorption of essential fatty acids; diversion of lipids from adipose cells into bloodstream; defective carbohydrate and lipid metabolism which modifies the blood brain barrier; neuroendocrine membrane alteration causing severe endocrine impairment; changes in the negative feedback mechanism which escalate the body’s use of bioenergy; derangement of the appetite center which causes a constant sensation of satiety; replacement of the correct body image with the premorbid one that encourages poor judgement concerning food intake and self-support. The loop-like nature of this mechanism perpetuates the disease. |
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| AbstractList | We believe anorexia nervosa is the result of a disruption in bioenergy homeostasis induced by lipid dysregulation. This disruption has two major determinants: (1) a biological predisposition to primary multihormonal disharmony linked to post-pubertal growth and development; and (2) an acquired abnormal lipid-induced loop operation precipitated by inappropriate diet. We present a step-by-step model describing the cascade of disorders that culminates in anorexia nervosa: defective digestion and absorption of essential fatty acids; diversion of lipids from adipose cells into bloodstream; defective carbohydrate and lipid metabolism which modifies the blood brain barrier; neuroendocrine membrane alteration causing severe endocrine impairment; changes in the negative feedback mechanism which escalate the body's use of bioenergy; derangement of the appetite center which causes a constant sensation of satiety; replacement of the correct body image with the premorbid one that encourages poor judgement concerning food intake and self-support. The loop-like nature of this mechanism perpetuates the disease. |
| Author | Naisberg, Y. Modai, I. Weizman, A. |
| Author_xml | – sequence: 1 givenname: Y. surname: Naisberg fullname: Naisberg, Y. organization: Sha’ar Menashe Mental Health Center, Mobile Post Hefer, Israel – sequence: 2 givenname: I. surname: Modai fullname: Modai, I. organization: Sha’ar Menashe Mental Health Center, Mobile Post Hefer, Israel – sequence: 3 givenname: A. surname: Weizman fullname: Weizman, A. organization: Petah Tikva and Sackler Faculty of Medicine, Gehah Psychiatric Hospital, Tel Aviv University, Beilinson Campus, Tel Aviv |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11339847$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3389_fendo_2021_613983 crossref_primary_10_1155_2013_483145 crossref_primary_10_3390_nu11092208 crossref_primary_10_1186_s40337_021_00408_6 crossref_primary_10_1111_j_1365_2362_2004_01415_x crossref_primary_10_1016_j_plefa_2019_01_001 crossref_primary_10_1016_j_regpep_2012_12_010 |
| Cites_doi | 10.1002/1098-108X(199505)17:4<337::AID-EAT2260170405>3.0.CO;2-Q 10.1016/S0003-9993(95)80558-3 10.1146/annurev.me.42.020191.001225 10.1016/0006-3223(93)90205-R 10.1016/S0025-7125(05)70116-4 10.1097/00075197-200001000-00006 10.1016/S0149-7634(05)80025-9 10.1530/eje.0.1320450 10.1192/bjp.151.6.785 10.1515/JPEM.2000.13.2.195 10.1016/0306-4530(95)00001-5 10.1111/j.1749-6632.1989.tb53228.x 10.1016/0006-3223(90)90032-W 10.1023/A:1007621302109 10.1016/0167-5699(94)90205-4 10.1054/mehy.1996.0306 10.1210/jcem.85.3.6447 10.1159/000288924 10.1007/s11745-999-0350-3 10.1016/0361-9230(94)00199-B 10.1093/ajcn/60.5.666 10.1016/S0271-5317(05)80225-8 |
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| Snippet | We believe anorexia nervosa is the result of a disruption in bioenergy homeostasis induced by lipid dysregulation. This disruption has two major determinants:... |
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| SubjectTerms | Adipose Tissue - metabolism Anorexia Nervosa - etiology Anorexia Nervosa - metabolism Appetite - physiology Body Image Digestive System Physiological Phenomena Energy Metabolism Homeostasis Humans Nutrition Disorders - metabolism Regional Blood Flow |
| Title | Metabolic bioenergy homeostatic disruption: a cause of anorexia nervosa |
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