Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis

• Published in: Development (Cambridge) Vol. 134; no. 5; pp. 999 - 1009
• Main Authors: Wu, Victoria M, Yu, Marcus H, Paik, Raehum, Banerjee, Swati, Liang, Zhiguo, Paul, Sarah M, Bhat, Manzoor A, Beitel, Greg J
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 01.03.2007
• Subjects: Amidohydrolases - metabolism; Amino Acid Sequence; Animals; Cell Adhesion; Cell Adhesion Molecules, Neuronal - metabolism; Cell Polarity; Drosophila; Drosophila - genetics; Drosophila - growth & development; Drosophila - physiology; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Drosophila Proteins - physiology; Guanylate Cyclase - genetics; Guanylate Cyclase - physiology; Guanylate Kinases - genetics; Guanylate Kinases - physiology; Intercellular Junctions - metabolism; Membrane Proteins - genetics; Membrane Proteins - physiology; Molecular Sequence Data; Phylogeny; Trachea - growth & development; Trachea - physiology

Epithelial tubes are the functional units of many organs, but little is known about how tube sizes are established. Using the Drosophila tracheal system as a model, we previously showed that mutations in varicose ( vari ) cause tubes to become elongated without increasing cell number. Here we show v...