Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis
Epithelial tubes are the functional units of many organs, but little is known about how tube sizes are established. Using the Drosophila tracheal system as a model, we previously showed that mutations in varicose ( vari ) cause tubes to become elongated without increasing cell number. Here we show v...
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Published in | Development (Cambridge) Vol. 134; no. 5; pp. 999 - 1009 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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The Company of Biologists Limited
01.03.2007
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Abstract | Epithelial tubes are the functional units of many organs, but little is known about how tube sizes are established. Using the Drosophila tracheal system as a model, we previously showed that mutations in varicose ( vari ) cause tubes to become elongated without increasing cell number. Here we show vari is required for accumulation of the tracheal size-control proteins Vermiform and Serpentine in the tracheal lumen. We also show that vari is an essential septate junction (SJ) gene encoding a membrane associated guanylate kinase (MAGUK). In vivo analyses of domains important for MAGUK scaffolding functions demonstrate that while the Vari HOOK domain is essential, the L27 domain is dispensable. Phylogenetic analyses reveal that Vari helps define a new MAGUK subgroup that includes mammalian PALS2. Importantly, both Vari and PALS2 are basolateral, and the interaction of Vari with the cell-adhesion protein Neurexin IV parallels the interaction of PALS2 and another cell-adhesion protein, Necl-2. Vari therefore bolsters the similarity between Drosophila and vertebrate epithelial basolateral regions, which had previously been limited to the common basolateral localization of Scrib, Dlg and Lgl, proteins required for epithelial polarization at the beginning of embryogenesis. However, by contrast to Scrib, Dlg and Lgl, Vari is not required for cell polarity but rather is part of a cell-adhesion complex. Thus, Vari fundamentally extends the similarity of Drosophila and vertebrate basolateral regions from sharing only polarity complexes to sharing both polarity and cell-adhesion complexes. |
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AbstractList | Epithelial tubes are the functional units of many organs, but little is known about how tube sizes are established. Using the Drosophila tracheal system as a model, we previously showed that mutations in varicose (vari) cause tubes to become elongated without increasing cell number. Here we show vari is required for accumulation of the tracheal size-control proteins Vermiform and Serpentine in the tracheal lumen. We also show that vari is an essential septate junction (SJ) gene encoding a membrane associated guanylate kinase (MAGUK). In vivo analyses of domains important for MAGUK scaffolding functions demonstrate that while the Vari HOOK domain is essential, the L27 domain is dispensable. Phylogenetic analyses reveal that Vari helps define a new MAGUK subgroup that includes mammalian PALS2. Importantly, both Vari and PALS2 are basolateral, and the interaction of Vari with the cell-adhesion protein Neurexin IV parallels the interaction of PALS2 and another cell-adhesion protein, Necl-2. Vari therefore bolsters the similarity between Drosophila and vertebrate epithelial basolateral regions, which had previously been limited to the common basolateral localization of Scrib, Dlg and Lgl, proteins required for epithelial polarization at the beginning of embryogenesis. However, by contrast to Scrib, Dlg and Lgl, Vari is not required for cell polarity but rather is part of a cell-adhesion complex. Thus, Vari fundamentally extends the similarity of Drosophila and vertebrate basolateral regions from sharing only polarity complexes to sharing both polarity and cell-adhesion complexes. Epithelial tubes are the functional units of many organs, but little is known about how tube sizes are established. Using the Drosophilatracheal system as a model, we previously showed that mutations in varicose (vari) cause tubes to become elongated without increasing cell number. Here we show vari is required for accumulation of the tracheal size-control proteins Vermiform and Serpentine in the tracheal lumen. We also show that vari is an essential septate junction (SJ) gene encoding a membrane associated guanylate kinase (MAGUK). In vivo analyses of domains important for MAGUK scaffolding functions demonstrate that while the Vari HOOK domain is essential, the L27 domain is dispensable. Phylogenetic analyses reveal that Vari helps define a new MAGUK subgroup that includes mammalian PALS2. Importantly, both Vari and PALS2 are basolateral,and the interaction of Vari with the cell-adhesion protein Neurexin IV parallels the interaction of PALS2 and another cell-adhesion protein, Necl-2. Vari therefore bolsters the similarity between Drosophila and vertebrate epithelial basolateral regions, which had previously been limited to the common basolateral localization of Scrib, Dlg and Lgl, proteins required for epithelial polarization at the beginning of embryogenesis. However, by contrast to Scrib, Dlg and Lgl, Vari is not required for cell polarity but rather is part of a cell-adhesion complex. Thus, Vari fundamentally extends the similarity of Drosophila and vertebrate basolateral regions from sharing only polarity complexes to sharing both polarity and cell-adhesion complexes. Epithelial tubes are the functional units of many organs, but little is known about how tube sizes are established. Using the Drosophila tracheal system as a model, we previously showed that mutations in varicose ( vari ) cause tubes to become elongated without increasing cell number. Here we show vari is required for accumulation of the tracheal size-control proteins Vermiform and Serpentine in the tracheal lumen. We also show that vari is an essential septate junction (SJ) gene encoding a membrane associated guanylate kinase (MAGUK). In vivo analyses of domains important for MAGUK scaffolding functions demonstrate that while the Vari HOOK domain is essential, the L27 domain is dispensable. Phylogenetic analyses reveal that Vari helps define a new MAGUK subgroup that includes mammalian PALS2. Importantly, both Vari and PALS2 are basolateral, and the interaction of Vari with the cell-adhesion protein Neurexin IV parallels the interaction of PALS2 and another cell-adhesion protein, Necl-2. Vari therefore bolsters the similarity between Drosophila and vertebrate epithelial basolateral regions, which had previously been limited to the common basolateral localization of Scrib, Dlg and Lgl, proteins required for epithelial polarization at the beginning of embryogenesis. However, by contrast to Scrib, Dlg and Lgl, Vari is not required for cell polarity but rather is part of a cell-adhesion complex. Thus, Vari fundamentally extends the similarity of Drosophila and vertebrate basolateral regions from sharing only polarity complexes to sharing both polarity and cell-adhesion complexes. |
Author | Sarah M. Paul Greg J. Beitel Victoria M. Wu Marcus H. Yu Raehum Paik Manzoor A. Bhat Swati Banerjee Zhiguo Liang |
AuthorAffiliation | 1 Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA 4 UNC Neuroscience Center, Curriculum in Neurobiology, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA 2 Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA 3 Department of Microbiology and Immunology, University of Illinois-Chicago, Chicago, IL 60612, USA |
AuthorAffiliation_xml | – name: 1 Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA – name: 4 UNC Neuroscience Center, Curriculum in Neurobiology, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA – name: 3 Department of Microbiology and Immunology, University of Illinois-Chicago, Chicago, IL 60612, USA – name: 2 Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA |
Author_xml | – sequence: 1 givenname: Victoria M surname: Wu fullname: Wu, Victoria M organization: Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA – sequence: 2 givenname: Marcus H surname: Yu fullname: Yu, Marcus H – sequence: 3 givenname: Raehum surname: Paik fullname: Paik, Raehum – sequence: 4 givenname: Swati surname: Banerjee fullname: Banerjee, Swati – sequence: 5 givenname: Zhiguo surname: Liang fullname: Liang, Zhiguo – sequence: 6 givenname: Sarah M surname: Paul fullname: Paul, Sarah M – sequence: 7 givenname: Manzoor A surname: Bhat fullname: Bhat, Manzoor A – sequence: 8 givenname: Greg J surname: Beitel fullname: Beitel, Greg J |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17267446$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/j.cub.2005.11.072 10.1126/science.1090289 10.1016/j.cub.2004.11.056 10.1146/annurev.biochem.74.082803.133339 10.1016/j.cub.2005.11.074 10.1016/S0925-4773(99)00098-2 10.1242/dev.00218 10.1083/jcb.200212054 10.1242/dev.127.20.4433 10.1016/j.cub.2006.01.008 10.1016/j.ceb.2004.07.008 10.1242/dev.127.15.3271 10.1093/genetics/158.4.1597 10.1534/genetics.106.063461 10.1016/S0167-4781(01)00191-9 10.1083/jcb.127.5.1345 10.1083/jcb.200309134 10.1242/dev.122.5.1395 10.1016/S0092-8674(00)81800-0 10.1002/(SICI)1520-6408(1997)20:2<111::AID-DVG4>3.0.CO;2-A 10.1242/dev.02710 10.1242/dev.02177 10.1242/dev.00691 10.1074/jbc.275.15.11425 10.1038/ng1314 10.1006/dbio.1994.1287 10.1016/S1534-5807(03)00275-2 10.1101/gad.1211604 10.1242/jcs.114.18.3219 10.1016/j.ydbio.2005.02.005 10.1083/jcb.134.6.1469 10.1016/j.neuron.2004.10.012 10.1016/S1097-2765(01)00416-6 10.1016/j.cell.2006.06.043 10.1016/S0962-8924(03)00083-7 10.1016/S0092-8674(00)80593-0 10.1006/dbio.2002.0799 10.1242/dev.125.24.4959 10.1016/S0092-8674(00)81725-0 10.1038/35001108 10.1186/gb-2002-3-12-research0088 10.1126/science.1072161 10.1016/j.ceb.2004.01.005 10.1016/S1097-2765(01)00411-7 10.1016/j.devcel.2005.07.012 10.1073/pnas.0506676102 10.1242/jcs.02597 10.1074/jbc.M305387200 10.1038/ncb896 10.1016/j.ydbio.2005.09.031 10.1083/jcb.109.6.2963 10.1242/jcs.01029 10.1146/annurev.genet.35.102401.091415 |
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References | 2021042605472427900_REF50 2021042605472427900_REF51 2021042605472427900_REF52 2021042605472427900_REF53 2021042605472427900_REF10 2021042605472427900_REF54 2021042605472427900_REF11 2021042605472427900_REF55 2021042605472427900_REF12 2021042605472427900_REF13 2021042605472427900_REF14 2021042605472427900_REF15 2021042605472427900_REF16 2021042605472427900_REF17 2021042605472427900_REF4 2021042605472427900_REF3 2021042605472427900_REF2 2021042605472427900_REF1 2021042605472427900_REF8 2021042605472427900_REF7 2021042605472427900_REF40 2021042605472427900_REF6 2021042605472427900_REF41 2021042605472427900_REF5 2021042605472427900_REF42 2021042605472427900_REF43 2021042605472427900_REF44 2021042605472427900_REF45 2021042605472427900_REF46 2021042605472427900_REF47 2021042605472427900_REF48 2021042605472427900_REF49 2021042605472427900_REF29 2021042605472427900_REF9 2021042605472427900_REF30 2021042605472427900_REF31 2021042605472427900_REF32 2021042605472427900_REF33 2021042605472427900_REF34 2021042605472427900_REF35 2021042605472427900_REF36 2021042605472427900_REF37 2021042605472427900_REF38 2021042605472427900_REF39 2021042605472427900_REF18 2021042605472427900_REF19 2021042605472427900_REF20 2021042605472427900_REF21 2021042605472427900_REF22 2021042605472427900_REF23 2021042605472427900_REF24 2021042605472427900_REF25 2021042605472427900_REF26 2021042605472427900_REF27 2021042605472427900_REF28 |
References_xml | – ident: 2021042605472427900_REF27 doi: 10.1016/j.cub.2005.11.072 – ident: 2021042605472427900_REF18 doi: 10.1126/science.1090289 – ident: 2021042605472427900_REF37 doi: 10.1016/j.cub.2004.11.056 – ident: 2021042605472427900_REF16 doi: 10.1146/annurev.biochem.74.082803.133339 – ident: 2021042605472427900_REF51 doi: 10.1016/j.cub.2005.11.074 – ident: 2021042605472427900_REF24 doi: 10.1016/S0925-4773(99)00098-2 – ident: 2021042605472427900_REF20 doi: 10.1242/dev.00218 – ident: 2021042605472427900_REF17 doi: 10.1083/jcb.200212054 – ident: 2021042605472427900_REF12 doi: 10.1242/dev.127.20.4433 – ident: 2021042605472427900_REF41 doi: 10.1016/j.cub.2006.01.008 – ident: 2021042605472427900_REF54 doi: 10.1016/j.ceb.2004.07.008 – ident: 2021042605472427900_REF6 doi: 10.1242/dev.127.15.3271 – ident: 2021042605472427900_REF10 doi: 10.1093/genetics/158.4.1597 – ident: 2021042605472427900_REF26 doi: 10.1534/genetics.106.063461 – ident: 2021042605472427900_REF48 doi: 10.1016/S0167-4781(01)00191-9 – ident: 2021042605472427900_REF40 doi: 10.1083/jcb.127.5.1345 – ident: 2021042605472427900_REF55 doi: 10.1083/jcb.200309134 – ident: 2021042605472427900_REF38 doi: 10.1242/dev.122.5.1395 – ident: 2021042605472427900_REF4 doi: 10.1016/S0092-8674(00)81800-0 – ident: 2021042605472427900_REF52 doi: 10.1002/(SICI)1520-6408(1997)20:2<111::AID-DVG4>3.0.CO;2-A – ident: 2021042605472427900_REF36 doi: 10.1242/dev.02710 – ident: 2021042605472427900_REF31 doi: 10.1242/dev.02177 – ident: 2021042605472427900_REF35 doi: 10.1242/dev.00691 – ident: 2021042605472427900_REF21 doi: 10.1074/jbc.275.15.11425 – ident: 2021042605472427900_REF45 doi: 10.1038/ng1314 – ident: 2021042605472427900_REF34 doi: 10.1006/dbio.1994.1287 – ident: 2021042605472427900_REF5 doi: 10.1016/S1534-5807(03)00275-2 – ident: 2021042605472427900_REF8 doi: 10.1101/gad.1211604 – ident: 2021042605472427900_REF19 doi: 10.1242/jcs.114.18.3219 – ident: 2021042605472427900_REF32 doi: 10.1016/j.ydbio.2005.02.005 – ident: 2021042605472427900_REF53 doi: 10.1083/jcb.134.6.1469 – ident: 2021042605472427900_REF33 doi: 10.1016/j.neuron.2004.10.012 – ident: 2021042605472427900_REF43 doi: 10.1016/S1097-2765(01)00416-6 – ident: 2021042605472427900_REF49 doi: 10.1016/j.cell.2006.06.043 – ident: 2021042605472427900_REF50 doi: 10.1016/S0962-8924(03)00083-7 – ident: 2021042605472427900_REF7 doi: 10.1016/S0092-8674(00)80593-0 – ident: 2021042605472427900_REF15 doi: 10.1006/dbio.2002.0799 – ident: 2021042605472427900_REF11 doi: 10.1242/dev.125.24.4959 – ident: 2021042605472427900_REF22 doi: 10.1016/S0092-8674(00)81725-0 – ident: 2021042605472427900_REF9 doi: 10.1038/35001108 – ident: 2021042605472427900_REF46 doi: 10.1186/gb-2002-3-12-research0088 – ident: 2021042605472427900_REF14 – ident: 2021042605472427900_REF23 doi: 10.1126/science.1072161 – ident: 2021042605472427900_REF1 doi: 10.1016/j.ceb.2004.01.005 – ident: 2021042605472427900_REF29 doi: 10.1016/S1097-2765(01)00411-7 – ident: 2021042605472427900_REF47 doi: 10.1016/j.devcel.2005.07.012 – ident: 2021042605472427900_REF13 doi: 10.1073/pnas.0506676102 – ident: 2021042605472427900_REF28 doi: 10.1242/jcs.02597 – ident: 2021042605472427900_REF25 – ident: 2021042605472427900_REF39 doi: 10.1074/jbc.M305387200 – ident: 2021042605472427900_REF42 doi: 10.1038/ncb896 – ident: 2021042605472427900_REF2 doi: 10.1016/j.ydbio.2005.09.031 – ident: 2021042605472427900_REF30 doi: 10.1083/jcb.109.6.2963 – ident: 2021042605472427900_REF3 doi: 10.1242/jcs.01029 – ident: 2021042605472427900_REF44 doi: 10.1146/annurev.genet.35.102401.091415 |
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Snippet | Epithelial tubes are the functional units of many organs, but little is known about how tube sizes are established. Using the Drosophila tracheal system as a... Epithelial tubes are the functional units of many organs, but little is known about how tube sizes are established. Using the Drosophilatracheal system as a... Epithelial tubes are the functional units of many organs, but little is known about how tube sizes are established. Using the Drosophila tracheal system as a... |
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SubjectTerms | Amidohydrolases - metabolism Amino Acid Sequence Animals Cell Adhesion Cell Adhesion Molecules, Neuronal - metabolism Cell Polarity Drosophila Drosophila - genetics Drosophila - growth & development Drosophila - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Drosophila Proteins - physiology Guanylate Cyclase - genetics Guanylate Cyclase - physiology Guanylate Kinases - genetics Guanylate Kinases - physiology Intercellular Junctions - metabolism Membrane Proteins - genetics Membrane Proteins - physiology Molecular Sequence Data Phylogeny Trachea - growth & development Trachea - physiology |
Title | Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis |
URI | http://dev.biologists.org/content/134/5/999.abstract https://www.ncbi.nlm.nih.gov/pubmed/17267446 https://search.proquest.com/docview/19571007 https://search.proquest.com/docview/68996579 https://pubmed.ncbi.nlm.nih.gov/PMC1955473 |
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