"Carryback": effect of viscous liquid controls on the preceding sample analyzed with the SMA II continuous-flow analyzer
We systematically studied the "carryback" effect of ethylene glycol-based controls on the preceding sample on an SMA II continuous-flow analyzer. Including Beckman Level 1 unassayed liquid control material as a sample lowered the 12 analyte values of the preceding sample by an average of 2...
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Published in | Clinical chemistry (Baltimore, Md.) Vol. 31; no. 11; pp. 1896 - 1899 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
Am Assoc Clin Chem
01.11.1985
American Association for Clinical Chemistry |
Subjects | |
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Abstract | We systematically studied the "carryback" effect of ethylene glycol-based controls on the preceding sample on an SMA II continuous-flow analyzer. Including Beckman Level 1 unassayed liquid control material as a sample lowered the 12 analyte values of the preceding sample by an average of 2.7%, Level 2 (the most viscous) by an average of 4.4%, and Level 3 by 3.2%. Water-reconstituted lyophilized control material caused no carryback effect, but lyophilized control reconstituted with 330 mL/L ethylene glycol decreased the preceding sample's results by 4.1% (average carryback). We believe that carryback is caused by the drag placed on the sample line by a viscous sample, which decreases the volume of the preceding sample that is delivered to the reagent or pre-dilution mixing coils. Our findings were confirmed on another SMA II. Limited study of a SMAC analyzer gave inconclusive results, but further evaluation of continuous-flow systems for carryback is warranted. Carryback substantially increases total analytical variability. |
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AbstractList | We systematically studied the "carryback" effect of ethylene glycol-based controls on the preceding sample on an SMA II continuous-flow analyzer. Including Beckman Level 1 unassayed liquid control material as a sample lowered the 12 analyte values of the preceding sample by an average of 2.7%, Level 2 (the most viscous) by an average of 4.4%, and Level 3 by 3.2%. Water-reconstituted lyophilized control material caused no carryback effect, but lyophilized control reconstituted with 330 mL/L ethylene glycol decreased the preceding sample's results by 4.1% (average carryback). We believe that carryback is caused by the drag placed on the sample line by a viscous sample, which decreases the volume of the preceding sample that is delivered to the reagent or pre-dilution mixing coils. Our findings were confirmed on another SMA II. Limited study of a SMAC analyzer gave inconclusive results, but further evaluation of continuous-flow systems for carryback is warranted. Carryback substantially increases total analytical variability. Abstract We systematically studied the "carryback" effect of ethylene glycol-based controls on the preceding sample on an SMA II continuous-flow analyzer. Including Beckman Level 1 unassayed liquid control material as a sample lowered the 12 analyte values of the preceding sample by an average of 2.7%, Level 2 (the most viscous) by an average of 4.4%, and Level 3 by 3.2%. Water-reconstituted lyophilized control material caused no carryback effect, but lyophilized control reconstituted with 330 mL/L ethylene glycol decreased the preceding sample's results by 4.1% (average carryback). We believe that carryback is caused by the drag placed on the sample line by a viscous sample, which decreases the volume of the preceding sample that is delivered to the reagent or pre-dilution mixing coils. Our findings were confirmed on another SMA II. Limited study of a SMAC analyzer gave inconclusive results, but further evaluation of continuous-flow systems for carryback is warranted. Carryback substantially increases total analytical variability. |
Author | Lepoff, RB Kerr, C McAvoy, M Smith, C Gallomore, MD Winter, SD |
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Keywords | Ethylene glycol Critical study Freeze drying Sample preparation Measurement accuracy Automatic analyzer |
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Snippet | We systematically studied the "carryback" effect of ethylene glycol-based controls on the preceding sample on an SMA II continuous-flow analyzer. Including... Abstract We systematically studied the "carryback" effect of ethylene glycol-based controls on the preceding sample on an SMA II continuous-flow analyzer.... |
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SubjectTerms | Analytical biochemistry: general aspects, technics, instrumentation Analytical, structural and metabolic biochemistry Autoanalysis - instrumentation Biological and medical sciences Blood Chemical Analysis - instrumentation Chemistry, Clinical - instrumentation Ethylene Glycol Ethylene Glycols Freeze Drying Fundamental and applied biological sciences. Psychology Humans Specimen Handling Viscosity Water |
Title | "Carryback": effect of viscous liquid controls on the preceding sample analyzed with the SMA II continuous-flow analyzer |
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