Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer

• Published in: Theranostics Vol. 10; no. 5; pp. 2095 - 2114
• Main Authors: Harrington, Brittney S, He, Yaowu, Khan, Tashbib, Puttick, Simon, Conroy, Paul J, Kryza, Thomas, Cuda, Tahleesa, Sokolowski, Kamil A, Tse, Brian Wc, Robbins, Katherine K, Arachchige, Buddhika J, Stehbens, Samantha J, Pollock, Pamela M, Reed, Sarah, Weroha, S John, Haluska, Paul, Salomon, Carlos, Lourie, Rohan, Perrin, Lewis C, Law, Ruby H P, Whisstock, James C, Hooper, John D
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2020; Ivyspring International Publisher
• Subjects: Animals; Antibodies; Antigens, Neoplasm - immunology; Cancer therapies; Cell adhesion & migration; Cell Adhesion Molecules - antagonists & inhibitors; Cell Adhesion Molecules - immunology; Cell Line, Tumor; Cell Membrane - metabolism; Cell Movement - immunology; Chemotherapy; Female; Flow cytometry; Immunoconjugates - immunology; Kinases; Medical prognosis; Membrane Proteins - metabolism; Metastasis; Mice; Models, Animal; Ovarian cancer; Ovarian Neoplasms - metabolism; Phosphorylation; Positron-Emission Tomography - methods; Proteins; Radioisotopes - chemistry; Radioisotopes - metabolism; Research Paper; Signal transduction; src-Family Kinases - metabolism; Surface Plasmon Resonance - methods; Transplantation, Heterologous - methods; Zirconium - chemistry; Zirconium - metabolism; immuno-conjugate; CDCP1; antibody; ovarian cancer

CUB-domain containing protein 1 (CDCP1) is a cancer associated cell surface protein that amplifies pro-tumorigenic signalling by other receptors including EGFR and HER2. Its potential as a cancer target is supported by studies showing that anti-CDCP1 antibodies inhibit cell migration and survival ,...