Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models
Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as “Marcela” or “Macela”. The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemic, mainly t...
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Published in | Journal of ethnopharmacology Vol. 130; no. 2; pp. 334 - 339 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
20.07.2010
Amsterdam; New York: Elsevier Elsevier |
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Abstract | Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as “Marcela” or “Macela”. The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemic, mainly to treat gastrointestinal disorders such as gastric ulcers and dyspepsia. This study was conducted to evaluate and contribute to validating the antiulcer activity of hydroalcoholic extract of inflorescences
of Achyrocline satureoides. The results show that the hydroalcoholics extract of
Achyrocline satureoides presents gastroprotective activity, as evidenced by the different ulcer models assayed. The data suggest that the effectiveness of the extract in the prevention and healing of ulcers is based on its ability to stimulate the synthesis of mucus, an important gastroprotective factor. Besides, the results obtained in this work suggest that preparations obtained from
Achyrocline satureoides could be used for the development of new phytotherapic drugs to treat gastric ulcer.
Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as “Marcela” or “Macela”. The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemic, mainly to treat gastrointestinal disorders such as gastric ulcers and dyspepsia. However, the antiulcer properties of this species have not yet been fully studied.
This study was conducted to evaluate and contribute to validating the antiulcer activity of hydroalcoholic extract of inflorescences
of Achyrocline satureoides.
The antiulcer assays were performed using the ethanol-induced ulcer, and nonsteroidal anti-inflammatory drug (NSAID)-induced ulcer protocols. Gastric secretion parameters were also evaluated (volume, pH and total acidity) by the pylorus ligated model, and the mucus in the gastric content was determined.
In the ethanol-induced ulcer model, it was observed that the treatment with
Achyrocline satureoides extract significantly reduced the lesion index by 75.1
±
8.6, 85.0
±
9.2, 86.6
±
7.4 and 75.5
±
5.3 for the groups treated with 100, 250 and 500
mg/kg of extract of inflorescences of
Achyrocline satureoides and the positive control (omeprazole 30
mg/kg), respectively. Significant inhibition was also observed in the lesion index in the indomethacin-induced ulcer model, with decreases of 62.5
±
7.1, 62.5
±
6.1, 63.6
±
5.5 and 96.2
±
3.6 for the groups treated with 100, 250 and 500
mg/kg of extract and the positive control (cimetidine 100
mg/kg), respectively. The parameters of gastric secretion (pH, volume, [H
+]) showed no alteration in the different doses of the treatment. On the other hand the treatment with the hydroalcoholic extract of
Achyrocline satureoides (100, 250 and 500
mg/kg), significantly increased mucus production (
p
<
0.01), when compared with the groups treated with indomethacin (100
mg/kg), cimetidine (100
mg/kg) and negative control (vehicle). No signs of toxicity was observed in the acute toxicity study.
The results of the present study show that hydroalcoholic extract of
Achyrocline satureoides displays antiulcer activity, as demonstrated by the significant inhibition of the formation of ulcers induced using different models. However, this activity appears not be related to the antisecretor mechanisms. Moreover, this work suggests that preparations obtained from
Achyrocline satureoides could be used for the development of new phytotherapic drugs for the treatment of gastric ulcer. |
---|---|
AbstractList | Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as "Marcela" or "Macela". The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemic, mainly to treat gastrointestinal disorders such as gastric ulcers and dyspepsia. However, the antiulcer properties of this species have not yet been fully studied.
This study was conducted to evaluate and contribute to validating the antiulcer activity of hydroalcoholic extract of inflorescences of Achyrocline satureoides.
The antiulcer assays were performed using the ethanol-induced ulcer, and nonsteroidal anti-inflammatory drug (NSAID)-induced ulcer protocols. Gastric secretion parameters were also evaluated (volume, pH and total acidity) by the pylorus ligated model, and the mucus in the gastric content was determined.
In the ethanol-induced ulcer model, it was observed that the treatment with Achyrocline satureoides extract significantly reduced the lesion index by 75.1+/-8.6, 85.0+/-9.2, 86.6+/-7.4 and 75.5+/-5.3 for the groups treated with 100, 250 and 500 mg/kg of extract of inflorescences of Achyrocline satureoides and the positive control (omeprazole 30 mg/kg), respectively. Significant inhibition was also observed in the lesion index in the indomethacin-induced ulcer model, with decreases of 62.5+/-7.1, 62.5+/-6.1, 63.6+/-5.5 and 96.2+/-3.6 for the groups treated with 100, 250 and 500 mg/kg of extract and the positive control (cimetidine 100 mg/kg), respectively. The parameters of gastric secretion (pH, volume, [H(+)]) showed no alteration in the different doses of the treatment. On the other hand the treatment with the hydroalcoholic extract of Achyrocline satureoides (100, 250 and 500 mg/kg), significantly increased mucus production (p<0.01), when compared with the groups treated with indomethacin (100 mg/kg), cimetidine (100 mg/kg) and negative control (vehicle). No signs of toxicity was observed in the acute toxicity study.
The results of the present study show that hydroalcoholic extract of Achyrocline satureoides displays antiulcer activity, as demonstrated by the significant inhibition of the formation of ulcers induced using different models. However, this activity appears not be related to the antisecretor mechanisms. Moreover, this work suggests that preparations obtained from Achyrocline satureoides could be used for the development of new phytotherapic drugs for the treatment of gastric ulcer. Ethnopharmacological relevance: Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as “Marcela” or “Macela”. The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemic, mainly to treat gastrointestinal disorders such as gastric ulcers and dyspepsia. However, the antiulcer properties of this species have not yet been fully studied. Aim of the study: This study was conducted to evaluate and contribute to validating the antiulcer activity of hydroalcoholic extract of inflorescences of Achyrocline satureoides. Materials and methods: The antiulcer assays were performed using the ethanol-induced ulcer, and nonsteroidal anti-inflammatory drug (NSAID)-induced ulcer protocols. Gastric secretion parameters were also evaluated (volume, pH and total acidity) by the pylorus ligated model, and the mucus in the gastric content was determined. Results: In the ethanol-induced ulcer model, it was observed that the treatment with Achyrocline satureoides extract significantly reduced the lesion index by 75.1±8.6, 85.0±9.2, 86.6±7.4 and 75.5±5.3 for the groups treated with 100, 250 and 500mg/kg of extract of inflorescences of Achyrocline satureoides and the positive control (omeprazole 30mg/kg), respectively. Significant inhibition was also observed in the lesion index in the indomethacin-induced ulcer model, with decreases of 62.5±7.1, 62.5±6.1, 63.6±5.5 and 96.2±3.6 for the groups treated with 100, 250 and 500mg/kg of extract and the positive control (cimetidine 100mg/kg), respectively. The parameters of gastric secretion (pH, volume, [H⁺]) showed no alteration in the different doses of the treatment. On the other hand the treatment with the hydroalcoholic extract of Achyrocline satureoides (100, 250 and 500mg/kg), significantly increased mucus production (p <0.01), when compared with the groups treated with indomethacin (100mg/kg), cimetidine (100mg/kg) and negative control (vehicle). No signs of toxicity was observed in the acute toxicity study. Conclusions: The results of the present study show that hydroalcoholic extract of Achyrocline satureoides displays antiulcer activity, as demonstrated by the significant inhibition of the formation of ulcers induced using different models. However, this activity appears not be related to the antisecretor mechanisms. Moreover, this work suggests that preparations obtained from Achyrocline satureoides could be used for the development of new phytotherapic drugs for the treatment of gastric ulcer. Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as “Marcela” or “Macela”. The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemic, mainly to treat gastrointestinal disorders such as gastric ulcers and dyspepsia. This study was conducted to evaluate and contribute to validating the antiulcer activity of hydroalcoholic extract of inflorescences of Achyrocline satureoides. The results show that the hydroalcoholics extract of Achyrocline satureoides presents gastroprotective activity, as evidenced by the different ulcer models assayed. The data suggest that the effectiveness of the extract in the prevention and healing of ulcers is based on its ability to stimulate the synthesis of mucus, an important gastroprotective factor. Besides, the results obtained in this work suggest that preparations obtained from Achyrocline satureoides could be used for the development of new phytotherapic drugs to treat gastric ulcer. Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as “Marcela” or “Macela”. The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemic, mainly to treat gastrointestinal disorders such as gastric ulcers and dyspepsia. However, the antiulcer properties of this species have not yet been fully studied. This study was conducted to evaluate and contribute to validating the antiulcer activity of hydroalcoholic extract of inflorescences of Achyrocline satureoides. The antiulcer assays were performed using the ethanol-induced ulcer, and nonsteroidal anti-inflammatory drug (NSAID)-induced ulcer protocols. Gastric secretion parameters were also evaluated (volume, pH and total acidity) by the pylorus ligated model, and the mucus in the gastric content was determined. In the ethanol-induced ulcer model, it was observed that the treatment with Achyrocline satureoides extract significantly reduced the lesion index by 75.1 ± 8.6, 85.0 ± 9.2, 86.6 ± 7.4 and 75.5 ± 5.3 for the groups treated with 100, 250 and 500 mg/kg of extract of inflorescences of Achyrocline satureoides and the positive control (omeprazole 30 mg/kg), respectively. Significant inhibition was also observed in the lesion index in the indomethacin-induced ulcer model, with decreases of 62.5 ± 7.1, 62.5 ± 6.1, 63.6 ± 5.5 and 96.2 ± 3.6 for the groups treated with 100, 250 and 500 mg/kg of extract and the positive control (cimetidine 100 mg/kg), respectively. The parameters of gastric secretion (pH, volume, [H +]) showed no alteration in the different doses of the treatment. On the other hand the treatment with the hydroalcoholic extract of Achyrocline satureoides (100, 250 and 500 mg/kg), significantly increased mucus production ( p < 0.01), when compared with the groups treated with indomethacin (100 mg/kg), cimetidine (100 mg/kg) and negative control (vehicle). No signs of toxicity was observed in the acute toxicity study. The results of the present study show that hydroalcoholic extract of Achyrocline satureoides displays antiulcer activity, as demonstrated by the significant inhibition of the formation of ulcers induced using different models. However, this activity appears not be related to the antisecretor mechanisms. Moreover, this work suggests that preparations obtained from Achyrocline satureoides could be used for the development of new phytotherapic drugs for the treatment of gastric ulcer. |
Author | Santin, José Roberto Niero, Rivaldo de Andrade, Sérgio Faloni Lemos, Marivane Júnior, Luiz Carlos Klein |
Author_xml | – sequence: 1 givenname: José Roberto surname: Santin fullname: Santin, José Roberto – sequence: 2 givenname: Marivane surname: Lemos fullname: Lemos, Marivane – sequence: 3 givenname: Luiz Carlos Klein surname: Júnior fullname: Júnior, Luiz Carlos Klein – sequence: 4 givenname: Rivaldo surname: Niero fullname: Niero, Rivaldo – sequence: 5 givenname: Sérgio Faloni surname: de Andrade fullname: de Andrade, Sérgio Faloni email: faloni@univali.br, sfaloni@bol.com.br |
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Keywords | Gastroprotective Achyrocline satureoides Antiulcerogenic activity Marcela Pharmacognosy Antiulcer agent Compositae Medicinal plant Folk medicine Dicotyledones Angiospermae Plant origin Spermatophyta |
Language | English |
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Snippet | Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as “Marcela” or “Macela”. The infusion obtained from inflorescences of... Ethnopharmacological relevance: Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as “Marcela” or “Macela”. The infusion... Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as "Marcela" or "Macela". The infusion obtained from inflorescences of... |
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StartPage | 334 |
SubjectTerms | Achyrocline Achyrocline satureioides Achyrocline satureoides animal disease models Animals anti-ulcer activity Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - toxicity Antiulcerogenic activity Biological and medical sciences Brazil Cimetidine - pharmacology Cytoprotection Disease Models, Animal disease prevention Dose-Response Relationship, Drug Ethanol ethnobotany gastric acid Gastric Acid - secretion Gastric Acidity Determination Gastric Mucosa - drug effects Gastric Mucosa - pathology Gastric Mucosa - secretion gastrointestinal agents Gastroprotective General pharmacology Indomethacin inflorescences lesions (animal) Marcela Medical sciences medicinal plants Medicine, Traditional mucus Mucus - secretion no observed adverse effect level Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plant Extracts - toxicity Rats Rats, Wistar regeneration Stomach Ulcer - chemically induced Stomach Ulcer - pathology Stomach Ulcer - physiopathology Stomach Ulcer - prevention & control stomach ulcers toxicity testing |
Title | Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models |
URI | https://dx.doi.org/10.1016/j.jep.2010.05.014 https://www.ncbi.nlm.nih.gov/pubmed/20546870 |
Volume | 130 |
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