Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity

• Published in: Biochimica et biophysica acta Vol. 1772; no. 4; pp. 413 - 421
• Main Authors: Arendt, Thomas, Brückner, Martina K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2007
• Subjects: Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Alzheimer's disease; Brain - pathology; Brain - physiopathology; Cell Cycle; Cell death; Humans; Models, Neurological; Neuronal Plasticity - physiology; Origin recognition complex; Origin Recognition Complex - analysis; Plasticity; Synapse; Synapses - pathology; Synapses - physiology; Synapse; Origin recognition complex; Cell death; Alzheimer's disease; Cell cycle; Plasticity

Higher cerebral functions are based upon a dynamic organization of neuronal networks. To form synaptic connections and to continuously re-shape them in a process of ongoing structural adaptation, neurons must permanently withdraw from the cell cycle. In other words, synaptic plasticity can only occu...