Effect of a Fixed Combination of Curcumin, Artemisia, Bromelain, and Black Pepper Oral Administration on Optical Coherence Tomography Angiography Indices in Patients with Diabetic Macular Edema

• Published in: Nutrients Vol. 14; no. 7; p. 1520
• Main Authors: Chiosi, Flavia, Rinaldi, Michele, Campagna, Giuseppe, Manzi, Gianluigi, De Angelis, Vincenzo, Calabrò, Francesco, D’Andrea, Luca, Tranfa, Fausto, Costagliola, Ciro
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.04.2022; MDPI
• Subjects: Administration, Oral; Antioxidants; Artemisia; Bromelains; Case-Control Studies; Curcumin - therapeutic use; Diabetes; Diabetes Mellitus - drug therapy; Diabetic retinopathy; Diabetic Retinopathy - diagnostic imaging; Diabetic Retinopathy - drug therapy; Disease; Edema; Fluorescein Angiography - methods; Humans; Inflammation; Macular Edema - drug therapy; Medical imaging; Microaneurysm; Patients; Piper nigrum; Prospective Studies; Retina; Retinal Vessels - diagnostic imaging; Retrospective Studies; Tomography; Tomography, Optical Coherence - methods; Vascular endothelial growth factor; Italy; OCTA; vascular flow density; artemisia; black pepper; diabetic retinopathy; bromelain; curcumin; diabetic macular edema

Background: To investigate the effects of a fixed combination of Curcumin (200 mg), Artemisia (80 mg), Bromelain (80 mg), and Black pepper (2 mg) on vascular parameters in mild to moderate diabetic macular edema (DME). Design: Prospective, case-control study. Methods: Fifty-six patients affected by...