Metal-free sulfonyl radical-initiated cascade cyclization to access sulfonated indolo[1,2-]quinolines

• Published in: Chemical communications (Cambridge, England) Vol. 55; no. 84; pp. 12615 - 12618
• Main Authors: Sun, Kai, Chen, Xiao-Lan, Zhang, Yin-Li, Li, Kai, Huang, Xian-Qiang, Peng, Yu-Yu, Qu, Ling-Bo, Yu, Bing
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 17.10.2019; Royal Society of Chemistry
• Subjects: Cascade chemical reactions; Chemistry; Chemistry, Multidisciplinary; Crystallography; cyclization reactions; Fluorescence; Hydrazides; image analysis; Indoles; Organic compounds; Physical Sciences; Quinoline; Science & Technology; QUINOLINE N-OXIDES; ONE-POT SYNTHESIS; ANNULATION; MEDIATED SULFONYLATION; STRATEGY; ALDEHYDES; QUINOXALIN-2(1H)-ONES; CATALYST; C-H ACTIVATION; EFFICIENT

A metal-free cascade reaction was developed for the synthesis of indolo[1,2- a ]quinoline derivatives from arylsulfonyl hydrazides and 1-(2-(arylethynyl)phenyl)indoles in the presence of TBAI/TBHP. Impressively, these products exhibit excellent fluorescence properties, which is promising for cell im...