Dickkopf 4 Alone and in Combination with Leucyl-tRNA Synthetase as a Good Prognostic Biomarker for Human Colorectal Cancer

• Published in: BioMed research international Vol. 2023; no. 1; p. 9057735
• Main Authors: Park, Su-Jeong, Cho, Jun Gi, Han, Sang-Heum, Kim, Yu-Mi, Pak, Min-Gyoung, Roh, Mee-Sook, Park, Joo-In
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2023; Hindawi Limited
• Subjects: Amino Acyl-tRNA Synthetases; Biomarkers; Cell growth; Cell Line, Tumor; Cell migration; Chemotherapy; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Esophagus; Humans; Leucine-tRNA ligase; Lung cancer; Lymph nodes; Lymphatic system; Medical prognosis; Medical research; Metastases; Metastasis; Neoplasm Recurrence, Local; Patients; Polyclonal antibodies; Prognosis; Proteins; Statistical significance; Surgery; Survival analysis; Transfer RNA; tRNA; Tumors; Wnt protein; β-Catenin; United States > US

The prognosis of patients with colorectal cancer (CRC) is affected by invasion and metastasis. Leucyl-tRNA synthetase (LARS) was shown to be related to the growth and migration of lung cancer cells. Dickkopf 4 (DKK4) is known as a Wnt/β-catenin pathway inhibitor, and its upregulation was reported in...