Tolerance to Ceftriaxone in Neisseria gonorrhoeae: Rapid Induction in WHO P Reference Strain and Detection in Clinical Isolates

• Published in: Antibiotics (Basel) Vol. 11; no. 11; p. 1480
• Main Authors: Balduck, Margaux, Laumen, Jolein Gyonne Elise, Abdellati, Saïd, De Baetselier, Irith, de Block, Tessa, Manoharan-Basil, Sheeba Santhini, Kenyon, Chris
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 26.10.2022; MDPI
• Subjects: Antibiotics; Antimicrobial agents; Antimicrobial resistance; Asymptomatic; Bacteria; Ceftriaxone; Clinical isolates; Cystic fibrosis; E coli; Experiments; Exposure; Gonorrhea; Infections; Metabolism; Minimum inhibitory concentration; Mutation; Neisseria gonorrhoeae; Phenotypes; Population; Sexually transmitted diseases; STD; tolerance; tolerance disc test

In addition to antimicrobial resistance, bacteria contain other mechanisms to survive antibiotic exposure such as tolerance, defined as the ability to slow metabolism by the extension of the lag phase without altering antimicrobial susceptibility. In a number of bacterial species, tolerance has been...