Caffeic acid phenethyl ester and its related compounds limit the functional alterations of the isolated mouse brain and liver mitochondria submitted to in vitro anoxia–reoxygenation: Relationship to their antioxidant activities

• Published in: Biochimica et biophysica acta Vol. 1780; no. 4; pp. 659 - 672
• Main Authors: Feng, Yun, Lu, Ying-Wei, Xu, Pei-Han, Long, Yuan, Wu, Wei-Min, Li, Wei, Wang, Rui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2008
• Subjects: Anaerobiosis; Animals; Anisotropy; Anoxia–reoxygenation; Antioxidants - metabolism; Brain - drug effects; Brain - metabolism; Caffeic acid phenethyl ester (CAPE); Caffeic Acids - chemistry; Caffeic Acids - pharmacology; Coumaric Acids - chemistry; Coumaric Acids - pharmacology; Cytochromes c - secretion; Dose-Response Relationship, Drug; Male; Mice; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria, Liver - drug effects; Mitochondria, Liver - metabolism; Mitochondrial Membranes - chemistry; Mitochondrial Membranes - drug effects; Mitochondrial Membranes - metabolism; Molecular Structure; Oxygen - pharmacology; Phenolic compounds; Phenylethyl Alcohol - analogs & derivatives; Phenylethyl Alcohol - chemistry; Phenylethyl Alcohol - pharmacology; Thiobarbituric Acid Reactive Substances - metabolism; Mitochondria; Anoxia–reoxygenation; Caffeic acid phenethyl ester (CAPE); Phenolic compounds

It is an important therapeutic strategy to protect mitochondria from oxidative stress, especially during ischemia–reperfusion. In the present study, an attempt has been made to evaluate the protective effects of caffeic acid phenethyl ester (CAPE) and its related phenolic compounds on mouse brain an...