The anti-hepatocellular carcinoma effect of Aidi injection was related to the synergistic action of cantharidin, formononetin, and isofraxidin through BIRC5, FEN1, and EGFR - Lu, Shan; Huang, Jiaqi; Zhang, Jingyuan; Wu, Chao; Huang, Zhihong; Tao, Xiaoyu; You, Leiming; Stalin, Antony; Chen, Meilin; Li, Jiaqi; Tan, Yingying; Wu, Zhishan; et al. (Journal of ethnopharmacology, 2024)
Keywords: active ingredients; Aidi injection; bioinformatics; BIRC5; cantharidin; carcinoma; Danio rerio; FEN1; formononetin; gene expression; genes; Hepatocellular carcinoma; hepatoma; meta-analysis; molecular biology; pharmacodynamics; PI3K-AKT signaling pathway; pro-apoptotic proteins; protective effect; RNA; synergism; Synergistic role; traditional medicine; xenotransplantation; Hepatocellular carcinoma; BIRC5; FEN1; PI3K-AKT signaling pathway; Aidi injection; Synergistic role