The contribution of α-dicarbonyl compound dependent radical formation to the antiseptic effect of honey

[Display omitted] •α-oxoaldehydes methylglyoxal, glyoxal and 3-deoxyglucosone are present in different honeys in varying concentrations.•Methylglyoxal and glyoxal form radicals with hydrogen peroxide and amino acids.•The balance of radical production and free radical quenching explains the wound hea...

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Published inJournal of functional foods Vol. 45; pp. 239 - 246
Main Authors Henatsch, Darius, den Hartog, Gertjan J.M., Duijvestijn, Adriaan M., Wolffs, Petra F., Phielix, Esther, Stokroos, Robert J., Briedé, Jacob J.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.06.2018
Elsevier
Subjects
Amino acid
Free radicals
Medical honey
Methylglyoxal
α-oxaldehyde
AA
M550
FH
Free radicals
ESR
AH
Lys
DMPO
GO
MID
3-DG
Medical honey
M30
P. aeroginosa
Methylglyoxal
Amino acid
S. aureus
RH
Arg
ROS
α-oxaldehyde
MG
E. coli
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Abstract [Display omitted] •α-oxoaldehydes methylglyoxal, glyoxal and 3-deoxyglucosone are present in different honeys in varying concentrations.•Methylglyoxal and glyoxal form radicals with hydrogen peroxide and amino acids.•The balance of radical production and free radical quenching explains the wound healing potential of honey. Honey is known for its wound healing potential. In this study we investigated free radical formation and inhibition in different honeys and the influence on bacterial growth inhibition. α-Oxaldehydes and free amino acids were shown to be present in manuka and non-manuka honeys. With electron spin resonance we measured that methylglyoxal (MG) and glyoxal (GO) form different carbon centered radicals under the influence of either hydrogen peroxide or arginine and lysine. These radicals were also formed in a combination of α-oxaldehydes and amino acids in artificial honey, which was quantified by the cytochrome C assay. Also, a strong bactericidal activity for MG and GO (minimum concentration 0.6 and 1.25 mM) was shown against different bacterial strains. Interestingly, honeys with a high MG content were shown to be better free radical scavengers for hydroxyl and superoxide radicals, implying a complex mechanism for free radical donation and scavenging in honey.
AbstractList Honey is known for its wound healing potential. In this study we investigated free radical formation and inhibition in different honeys and the influence on bacterial growth inhibition. α-Oxaldehydes and free amino acids were shown to be present in manuka and non-manuka honeys. With electron spin resonance we measured that methylglyoxal (MG) and glyoxal (GO) form different carbon centered radicals under the influence of either hydrogen peroxide or arginine and lysine. These radicals were also formed in a combination of α-oxaldehydes and amino acids in artificial honey, which was quantified by the cytochrome C assay. Also, a strong bactericidal activity for MG and GO (minimum concentration 0.6 and 1.25 mM) was shown against different bacterial strains. Interestingly, honeys with a high MG content were shown to be better free radical scavengers for hydroxyl and superoxide radicals, implying a complex mechanism for free radical donation and scavenging in honey.
[Display omitted] •α-oxoaldehydes methylglyoxal, glyoxal and 3-deoxyglucosone are present in different honeys in varying concentrations.•Methylglyoxal and glyoxal form radicals with hydrogen peroxide and amino acids.•The balance of radical production and free radical quenching explains the wound healing potential of honey. Honey is known for its wound healing potential. In this study we investigated free radical formation and inhibition in different honeys and the influence on bacterial growth inhibition. α-Oxaldehydes and free amino acids were shown to be present in manuka and non-manuka honeys. With electron spin resonance we measured that methylglyoxal (MG) and glyoxal (GO) form different carbon centered radicals under the influence of either hydrogen peroxide or arginine and lysine. These radicals were also formed in a combination of α-oxaldehydes and amino acids in artificial honey, which was quantified by the cytochrome C assay. Also, a strong bactericidal activity for MG and GO (minimum concentration 0.6 and 1.25 mM) was shown against different bacterial strains. Interestingly, honeys with a high MG content were shown to be better free radical scavengers for hydroxyl and superoxide radicals, implying a complex mechanism for free radical donation and scavenging in honey.
Author Duijvestijn, Adriaan M.
Henatsch, Darius
Briedé, Jacob J.
Stokroos, Robert J.
Wolffs, Petra F.
Phielix, Esther
den Hartog, Gertjan J.M.
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Keywords AA
M550
FH
Free radicals
ESR
AH
Lys
DMPO
GO
MID
3-DG
Medical honey
M30
P. aeroginosa
Methylglyoxal
Amino acid
S. aureus
RH
Arg
ROS
α-oxaldehyde
MG
E. coli
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Snippet [Display omitted] •α-oxoaldehydes methylglyoxal, glyoxal and 3-deoxyglucosone are present in different honeys in varying concentrations.•Methylglyoxal and...
Honey is known for its wound healing potential. In this study we investigated free radical formation and inhibition in different honeys and the influence on...
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StartPage 239
SubjectTerms Amino acid
Free radicals
Medical honey
Methylglyoxal
α-oxaldehyde
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Title The contribution of α-dicarbonyl compound dependent radical formation to the antiseptic effect of honey
URI https://dx.doi.org/10.1016/j.jff.2018.04.012
https://doaj.org/article/b7bf250ebe884ae299cd3dcc89dc3bb7
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