Gefitinib and Afatinib Show Potential Efficacy for Fanconi Anemia-Related Head and Neck Cancer

• Published in: Clinical cancer research Vol. 26; no. 12; pp. 3044 - 3057
• Main Authors: Montanuy, Helena, Martínez-Barriocanal, Águeda, Antonio Casado, José, Rovirosa, Llorenç, Ramírez, Maria José, Nieto, Rocío, Carrascoso-Rubio, Carlos, Riera, Pau, González, Alan, Lerma, Enrique, Lasa, Adriana, Carreras-Puigvert, Jordi, Helleday, Thomas, Bueren, Juan A, Arango, Diego, Minguillón, Jordi, Surrallés, Jordi
• Format: Journal Article
• Language: English
• Published: United States 15.06.2020
• Subjects: Medicin och hälsovetenskap

Fanconi anemia rare disease is characterized by bone marrow failure and a high predisposition to solid tumors, especially head and neck squamous cell carcinoma (HNSCC). Patients with Fanconi anemia with HNSCC are not eligible for conventional therapies due to high toxicity in healthy cells, predomin...