Treadmill training prevents bone loss by inhibition of PPARγ expression but not promoting of Runx2 expression in ovariectomized rats

• Published in: European journal of applied physiology Vol. 111; no. 8; pp. 1759 - 1767
• Main Authors: Chen, Yongjie, Wang, Shouhui, Bu, Shumin, Wang, Yingjie, Duan, Yushuang, Yang, Shaofeng
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.08.2011; Springer
• Subjects: Adipocytes; adipogenesis; Animal subjects; Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Blood; Bone Density - drug effects; Bone Density - genetics; Bone Density - physiology; Bone loss; Bone mineral density; Bone Resorption - genetics; Bone Resorption - metabolism; Bone Resorption - prevention & control; Bones; Cbfa-1 protein; Core Binding Factor Alpha 1 Subunit - genetics; Core Binding Factor Alpha 1 Subunit - metabolism; Differentiation; Down-Regulation - drug effects; Down-Regulation - genetics; Dual energy X-ray absorptiometry; Estrogen Replacement Therapy; Exercise physiology; Exercise Test; Female; Fundamental and applied biological sciences. Psychology; Human Physiology; Inhibition; Menopause; Occupational Medicine/Industrial Medicine; Original Article; Osteogenesis; osteogenic factor; Ovariectomy; Peroxisome proliferator-activated receptors; Peroxisomes; Physical Conditioning, Animal - physiology; Physical training; PPAR gamma - genetics; PPAR gamma - metabolism; Proteins; Rats; Rats, Sprague-Dawley; Running - physiology; Sports Medicine; Transcription factors; Treadmill ergometry; Triglycerides; Uterus; Vacuoles; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports; Western blotting; Women; Bone marrow adipogenesis; Osteoporosis; OVX rats; Treadmill training; Osteogenic factors; Human; Physical training; Ovariectomy; Rat; Diseases of the osteoarticular system; Rodentia; Vertebrata; Mammalia; Bone marrow; Inhibition; Osteopenia

Exercise training has been reported to prevent bone loss in ovariectomized (OVX) rats and postmenopausal women. We hypothesized that treadmill training inhibited adipogenesis and enhanced osteogenesis through the regulation of adipocyte differentiation factor peroxisome proliferators-activated recep...