A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD

Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linka...

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Published inJournal of clinical medicine Vol. 9; no. 9; p. 2737
Main Authors Hirano, Tsunahiko, Doi, Keiko, Matsunaga, Kazuto, Takahashi, Shun, Donishi, Tomohiro, Suga, Kazuyoshi, Oishi, Keiji, Yasuda, Kasumi, Mimura, Yusuke, Harada, Misa, Suizu, Sumiteru, Murakawa, Keita, Chikumoto, Ayumi, Ohteru, Yuichi, Matsuda, Kazuki, Uehara, Sho, Hamada, Kazuki, Ohata, Shuichiro, Murata, Yoriyuki, Yamaji, Yoshikazu, Asami-Noyama, Maki, Edakuni, Nobutaka, Kakugawa, Tomoyuki
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 24.08.2020
MDPI
Subjects
Age
Aging
Asthma
Biomarkers
Chronic illnesses
Chronic obstructive pulmonary disease
Clinical medicine
Cognitive ability
Comorbidity
Inflammation
Lifestyles
Lung diseases
Metabolic disorders
Musculoskeletal system
Proteins
Sedentary behavior
Trends
comorbidity
motoric cognitive risk
cognitive impairment
aging
GDF-15
sedentary
COPD
Online AccessGet full text
ISSN2077-0383
2077-0383
DOI10.3390/jcm9092737

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Abstract Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects (n = 14), asthmatics (n = 22), and COPD patients (n = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) (ρ = −0.43, p < 0.001) and MoCA-J (ρ = −0.44, p < 0.001), and Ex and MOCA-J showed a positive correlation (ρ = 0.52, p < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients.
AbstractList Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects ( n = 14), asthmatics ( n = 22), and COPD patients ( n = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) ( ρ = −0.43, p < 0.001) and MoCA-J ( ρ = −0.44, p < 0.001), and Ex and MOCA-J showed a positive correlation ( ρ = 0.52, p < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients.
Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects (n = 14), asthmatics (n = 22), and COPD patients (n = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) (ρ = −0.43, p < 0.001) and MoCA-J (ρ = −0.44, p < 0.001), and Ex and MOCA-J showed a positive correlation (ρ = 0.52, p < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients.
Sedentary behavior and cognitive impairment have a direct impact on patients' outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects ( = 14), asthmatics ( = 22), and COPD patients ( = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) ( = -0.43, < 0.001) and MoCA-J ( = -0.44, < 0.001), and Ex and MOCA-J showed a positive correlation ( = 0.52, < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients.
Sedentary behavior and cognitive impairment have a direct impact on patients' outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects (n = 14), asthmatics (n = 22), and COPD patients (n = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) (ρ = -0.43, p < 0.001) and MoCA-J (ρ = -0.44, p < 0.001), and Ex and MOCA-J showed a positive correlation (ρ = 0.52, p < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients.Sedentary behavior and cognitive impairment have a direct impact on patients' outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects (n = 14), asthmatics (n = 22), and COPD patients (n = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) (ρ = -0.43, p < 0.001) and MoCA-J (ρ = -0.44, p < 0.001), and Ex and MOCA-J showed a positive correlation (ρ = 0.52, p < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients.
Author Ohata, Shuichiro
Kakugawa, Tomoyuki
Suga, Kazuyoshi
Oishi, Keiji
Ohteru, Yuichi
Matsunaga, Kazuto
Doi, Keiko
Takahashi, Shun
Chikumoto, Ayumi
Harada, Misa
Yamaji, Yoshikazu
Edakuni, Nobutaka
Hirano, Tsunahiko
Asami-Noyama, Maki
Murata, Yoriyuki
Yasuda, Kasumi
Suizu, Sumiteru
Hamada, Kazuki
Matsuda, Kazuki
Uehara, Sho
Donishi, Tomohiro
Mimura, Yusuke
Murakawa, Keita
AuthorAffiliation 3 Department of System Neurophysiology, Graduate School of Wakayama Medical University, Wakayama 641-8510, Japan; tdonishi@wakayama-med.ac.jp
7 Department of Pulmonology and Gerontology Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan; tomoyukikakugawa@gmail.com
1 Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan; decem119@yamaguchi-u.ac.jp (K.D.); kazmatsu@yamaguchi-u.ac.jp (K.M.); hara-da@yamaguchi-u.ac.jp (M.H.); relativity.theory135@gmail.com (S.S.); murakawakeita124@gmail.com (K.M.); chiku05@yamaguchi-u.ac.jp (A.C.); yohteru@yamaguchi-u.ac.jp (Y.O.); k0m1a2t8s1u1d2a1@gmail.com (K.M.); n010eb.mie@gmail.com (S.U.); khamada@yamaguchi-u.ac.jp (K.H.); j015ebponyou@gmail.com (S.O.); yyamaji@yamaguchi-u.ac.jp (Y.Y.); noyamama@yamaguchi-u.ac.jp (M.A.-N.); edakuni@yamaguchi-u.ac.jp (N.E.)
2 Department of Neuropsychiatry, Wakayama Medical University, Wakayama 641-8510, Japan; t-shun@wakayama-m
AuthorAffiliation_xml – name: 7 Department of Pulmonology and Gerontology Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan; tomoyukikakugawa@gmail.com
– name: 5 Department of Medicine and Clinical Science, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan; ohishk@yamaguchi-u.ac.jp (K.O.); ymurata-ygc@umin.ac.jp (Y.M.)
– name: 1 Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan; decem119@yamaguchi-u.ac.jp (K.D.); kazmatsu@yamaguchi-u.ac.jp (K.M.); hara-da@yamaguchi-u.ac.jp (M.H.); relativity.theory135@gmail.com (S.S.); murakawakeita124@gmail.com (K.M.); chiku05@yamaguchi-u.ac.jp (A.C.); yohteru@yamaguchi-u.ac.jp (Y.O.); k0m1a2t8s1u1d2a1@gmail.com (K.M.); n010eb.mie@gmail.com (S.U.); khamada@yamaguchi-u.ac.jp (K.H.); j015ebponyou@gmail.com (S.O.); yyamaji@yamaguchi-u.ac.jp (Y.Y.); noyamama@yamaguchi-u.ac.jp (M.A.-N.); edakuni@yamaguchi-u.ac.jp (N.E.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32847145$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/nrm3823
10.1155/2018/8343705
10.1016/j.maturitas.2016.05.005
10.5966/sctm.2013-0055
10.1249/mss.0b013e3180616b27
10.1113/jphysiol.2004.081083
10.1016/j.ypmed.2004.06.003
10.1083/jcb.201607110
10.1111/j.1447-0594.2010.00585.x
10.1183/09031936.05.00034805
10.1016/j.resinv.2013.06.002
10.1186/1465-9921-12-3
10.1097/00005768-200208000-00021
10.1038/nm.4392
10.1016/S0140-6736(15)61340-X
10.1146/annurev-physiol-022516-034314
10.1016/j.cell.2019.07.033
10.1164/rccm.200407-855OC
10.1111/ggi.12724
10.1172/JCI120842
10.1183/13993003.01298-2016
10.1378/chest.10-2521
10.1186/s12931-017-0521-1
10.1373/clinchem.2016.255174
10.1016/j.expneurol.2004.10.011
10.1016/j.cytogfr.2013.05.003
10.1111/j.1749-6632.2002.tb02086.x
10.1183/09031936.00229714
10.1016/j.arr.2018.07.004
10.1183/09031936.00125109
10.3389/fnins.2019.00030
10.1038/nature07206
10.1016/j.tem.2018.05.002
10.1111/j.1532-5415.2005.53221.x
10.1212/WNL.0000000000007094
10.1093/gerona/gls191
10.1159/000330046
10.1159/000338607
10.1186/s12974-018-1059-y
10.1007/s004410051337
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2020 by the authors. 2020
Copyright_xml – notice: 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Keywords comorbidity
motoric cognitive risk
cognitive impairment
aging
GDF-15
sedentary
COPD
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References Miyamoto (ref_23) 2018; 2018
Barnes (ref_42) 2017; 79
Luan (ref_10) 2019; 178
Zhao (ref_41) 2019; 13
Hara (ref_27) 2006; 55
Cohen (ref_36) 2016; 93
Unsicker (ref_15) 2013; 24
Kolsum (ref_34) 2011; 12
Siqueira (ref_38) 2018; 15
Waschki (ref_4) 2011; 140
Haskell (ref_29) 2007; 39
Sugino (ref_24) 2012; 83
Fujiwara (ref_31) 2010; 10
Handschin (ref_9) 2008; 454
Matthews (ref_25) 2002; 34
Barnes (ref_43) 2015; 45
Pollack (ref_39) 2002; 959
Corre (ref_11) 2013; 2
Nasreddine (ref_30) 2005; 53
Minakata (ref_6) 2014; 52
Mullican (ref_12) 2018; 29
Miller (ref_32) 2005; 26
Chung (ref_14) 2017; 216
Mullican (ref_33) 2017; 23
Siu (ref_40) 2005; 565
Zhang (ref_37) 2005; 191
ref_45
Bottner (ref_13) 1999; 297
ref_22
Burkett (ref_26) 2005; 40
Martinez (ref_44) 2017; 18
ref_21
Pereiro (ref_3) 2012; 33
Murray (ref_2) 2015; 386
ref_1
Cardoso (ref_18) 2018; 47
Serrano (ref_16) 2014; 15
Fujita (ref_17) 2016; 16
Dodd (ref_7) 2010; 35
Jang (ref_19) 2018; 128
Walker (ref_35) 2019; 92
Verghese (ref_8) 2013; 68
Wollert (ref_20) 2017; 63
Pitta (ref_5) 2005; 171
Matsumura (ref_28) 2008; 56
References_xml – volume: 15
  start-page: 482
  year: 2014
  ident: ref_16
  article-title: Cellular senescence: From physiology to pathology
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3823
– volume: 2018
  start-page: 8343705
  year: 2018
  ident: ref_23
  article-title: Verification of a motion sensor for evaluating physical activity in COPD patients
  publication-title: Can. Respir. J.
  doi: 10.1155/2018/8343705
– volume: 93
  start-page: 73
  year: 2016
  ident: ref_36
  article-title: Cognition and gait in older people
  publication-title: Maturitas
  doi: 10.1016/j.maturitas.2016.05.005
– volume: 2
  start-page: 946
  year: 2013
  ident: ref_11
  article-title: Concise review: Growth differentiation factor 15 in pathology: A clinical role?
  publication-title: Stem Cells Transl. Med.
  doi: 10.5966/sctm.2013-0055
– volume: 55
  start-page: 385
  year: 2006
  ident: ref_27
  article-title: The relationship between body weight reduction and intensity of daily physical activities assessed with 3-dimension accelerometer
  publication-title: Jpn. J. Phys. Fit. Sports Med.
– volume: 56
  start-page: 60
  year: 2008
  ident: ref_28
  article-title: High-accuracy physical activity monitor utilizing three-axis accelerometer
  publication-title: Natl. Tech. Rep.
– volume: 39
  start-page: 1423
  year: 2007
  ident: ref_29
  article-title: Physical activity and public health: Updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
  publication-title: Med. Sci. Sports Exerc.
  doi: 10.1249/mss.0b013e3180616b27
– volume: 565
  start-page: 309
  year: 2005
  ident: ref_40
  article-title: Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2004.081083
– volume: 40
  start-page: 293
  year: 2005
  ident: ref_26
  article-title: How many days of pedometer monitoring predict weekly physical activity in adults?
  publication-title: Prev. Med.
  doi: 10.1016/j.ypmed.2004.06.003
– volume: 216
  start-page: 149
  year: 2017
  ident: ref_14
  article-title: Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201607110
– volume: 10
  start-page: 225
  year: 2010
  ident: ref_31
  article-title: Brief screening tool for mild cognitive impairment in older Japanese: Validation of the Japanese version of the Montreal Cognitive Assessment
  publication-title: Geriatr. Gerontol. Int.
  doi: 10.1111/j.1447-0594.2010.00585.x
– volume: 26
  start-page: 319
  year: 2005
  ident: ref_32
  article-title: Standardisation of spirometry
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.05.00034805
– volume: 52
  start-page: 41
  year: 2014
  ident: ref_6
  article-title: Reduced level of physical activity in Japanese patients with chronic obstructive pulmonary disease
  publication-title: Respir. Investig.
  doi: 10.1016/j.resinv.2013.06.002
– volume: 12
  start-page: 3
  year: 2011
  ident: ref_34
  article-title: Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD
  publication-title: Respir. Res.
  doi: 10.1186/1465-9921-12-3
– volume: 34
  start-page: 1376
  year: 2002
  ident: ref_25
  article-title: Sources of variance in daily physical activity levels as measured by an accelerometer
  publication-title: Med. Sci. Sports Exerc.
  doi: 10.1097/00005768-200208000-00021
– volume: 23
  start-page: 1150
  year: 2017
  ident: ref_33
  article-title: GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
  publication-title: Nat. Med.
  doi: 10.1038/nm.4392
– volume: 386
  start-page: 2145
  year: 2015
  ident: ref_2
  article-title: Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: Quantifying the epidemiological transition
  publication-title: Lancet
  doi: 10.1016/S0140-6736(15)61340-X
– volume: 79
  start-page: 517
  year: 2017
  ident: ref_42
  article-title: Senescence in COPD and its comorbidities
  publication-title: Ann. Rev. Physiol.
  doi: 10.1146/annurev-physiol-022516-034314
– volume: 178
  start-page: 1231
  year: 2019
  ident: ref_10
  article-title: GDF15 is an inflammation-induced central mediator of tissue tolerance
  publication-title: Cell
  doi: 10.1016/j.cell.2019.07.033
– ident: ref_1
– volume: 171
  start-page: 972
  year: 2005
  ident: ref_5
  article-title: Characteristics of physical activities in daily life in chronic obstructive pulmonary disease
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200407-855OC
– ident: ref_21
– volume: 16
  start-page: 17
  year: 2016
  ident: ref_17
  article-title: Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders
  publication-title: Geriatr. Gerontol. Int.
  doi: 10.1111/ggi.12724
– volume: 128
  start-page: 3662
  year: 2018
  ident: ref_19
  article-title: The role of mitochondria in aging
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI120842
– ident: ref_45
  doi: 10.1183/13993003.01298-2016
– volume: 140
  start-page: 331
  year: 2011
  ident: ref_4
  article-title: Physical activity is the strongest predictor of all-cause mortality in patients with COPD: A prospective cohort study
  publication-title: Chest
  doi: 10.1378/chest.10-2521
– volume: 18
  start-page: 42
  year: 2017
  ident: ref_44
  article-title: GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease
  publication-title: Respir. Res.
  doi: 10.1186/s12931-017-0521-1
– volume: 63
  start-page: 140
  year: 2017
  ident: ref_20
  article-title: Growth differentiation factor 15 as a biomarker in cardiovascular disease
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2016.255174
– volume: 191
  start-page: 318
  year: 2005
  ident: ref_37
  article-title: High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex
  publication-title: Exp. Neurol.
  doi: 10.1016/j.expneurol.2004.10.011
– volume: 24
  start-page: 373
  year: 2013
  ident: ref_15
  article-title: The multiple facets of the TGF-beta family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2013.05.003
– volume: 959
  start-page: 93
  year: 2002
  ident: ref_39
  article-title: The role of apoptosis in the normal aging brain, skeletal muscle, and heart
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.2002.tb02086.x
– volume: 45
  start-page: 790
  year: 2015
  ident: ref_43
  article-title: Mechanisms of development of multimorbidity in the elderly
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.00229714
– volume: 47
  start-page: 214
  year: 2018
  ident: ref_18
  article-title: Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
  publication-title: Ageing Res. Rev.
  doi: 10.1016/j.arr.2018.07.004
– volume: 35
  start-page: 913
  year: 2010
  ident: ref_7
  article-title: Cognitive function in COPD
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.00125109
– volume: 13
  start-page: 30
  year: 2019
  ident: ref_41
  article-title: Mitochondrial dysfunction in neural injury
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2019.00030
– volume: 454
  start-page: 463
  year: 2008
  ident: ref_9
  article-title: The role of exercise and PGC1alpha in inflammation and chronic disease
  publication-title: Nature
  doi: 10.1038/nature07206
– volume: 29
  start-page: 560
  year: 2018
  ident: ref_12
  article-title: Uniting GDF15 and GFRAL: Therapeutic opportunities in obesity and beyond
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2018.05.002
– volume: 53
  start-page: 695
  year: 2005
  ident: ref_30
  article-title: The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2005.53221.x
– volume: 92
  start-page: e1256
  year: 2019
  ident: ref_35
  article-title: Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000007094
– volume: 68
  start-page: 412
  year: 2013
  ident: ref_8
  article-title: Motoric cognitive risk syndrome and the risk of dementia
  publication-title: J. Gerontol. Ser. A Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/gls191
– volume: 83
  start-page: 300
  year: 2012
  ident: ref_24
  article-title: Validation of a compact motion sensor for the measurement of physical activity in patients with chronic obstructive pulmonary disease
  publication-title: Respiration
  doi: 10.1159/000330046
– volume: 33
  start-page: 226
  year: 2012
  ident: ref_3
  article-title: Prevalence and correlates of cognitive impairment in adults with subjective memory complaints in primary care centres
  publication-title: Dement. Geriatr. Cogn. Disord.
  doi: 10.1159/000338607
– volume: 15
  start-page: 28
  year: 2018
  ident: ref_38
  article-title: Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
  publication-title: J. Neuroinflammation
  doi: 10.1186/s12974-018-1059-y
– volume: 297
  start-page: 103
  year: 1999
  ident: ref_13
  article-title: Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues
  publication-title: Cell Tissue Res.
  doi: 10.1007/s004410051337
– ident: ref_22
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Snippet Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these...
Sedentary behavior and cognitive impairment have a direct impact on patients' outcomes. An energy metabolic disorder may be involved in the overlap of these...
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StartPage 2737
SubjectTerms Age
Aging
Asthma
Biomarkers
Chronic illnesses
Chronic obstructive pulmonary disease
Clinical medicine
Cognitive ability
Comorbidity
Inflammation
Lifestyles
Lung diseases
Metabolic disorders
Musculoskeletal system
Proteins
Sedentary behavior
Trends
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Title A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD
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