Structure−antigenicity relationship studies of the central conserved region of human respiratory syncytial virus protein G

• Published in: The journal of peptide research Vol. 60; no. 5; pp. 271 - 282
• Main Authors: Sugawara, M., Czaplicki, J., Ferrage, J., Milon, A., Haeuw, J.-F., Power, U. F., Corvaïa, N., Nguyen, T., Beck, A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.11.2002; Wiley
• Subjects: Antigens, Viral - chemistry; Antigens, Viral - immunology; BBG2Na; Biochemical Research Methods; Biochemistry & Molecular Biology; Circular Dichroism; exchange rate of NH protons; Humans; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; NMR; peptide structure and dynamics; Protein Conformation; Respiratory Syncytial Virus Vaccines - chemistry; Respiratory Syncytial Virus Vaccines - immunology; Respiratory Syncytial Virus, Human - chemistry; Respiratory Syncytial Virus, Human - immunology; RSV vaccine; Science & Technology; Structure-Activity Relationship; Vaccines, Subunit - chemistry; Vaccines, Subunit - immunology; Viral Envelope Proteins - chemistry; Viral Envelope Proteins - immunology; ALBUMIN-BINDING REGION; RECOMBINANT SUBUNIT VACCINE; NUCLEAR-MAGNETIC-RESONANCE; CHEMICAL-SHIFT; G-GLYCOPROTEIN; circular dichroism; SUBGROUP-A; RSV vaccine; CIRCULAR-DICHROISM SPECTRA; NMR; IMMUNOGENICITY; exchange rate of NH protons; peptide structure and dynamics; SECONDARY STRUCTURE; BBG2Na

: BBG2Na is a recombinant protein, composed in part of carrier protein BB and of the central conserved domain of the attachment glycoprotein G of human respiratory syncytial virus (HRSV) subgroup A. This protein is a potent vaccine candidate against HRSV. G2Na contains several contiguous B‐cell epit...