AcrDB update: Predicted 3D structures of anti‐CRISPRs in human gut viromes

• Published in: Protein science Vol. 34; no. 6; pp. e70177 - n/a
• Main Authors: Khatri, Minal, Shanmugam, N. R. Siva, Zhang, Xinpeng, Patel, Revanth Sai Kumar Reddy, Yin, Yanbin
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.06.2025; Wiley Subscription Services, Inc
• Subjects: anti‐CRISPR; anti‐defense genes; bacterial immunity; Bacteriophages - chemistry; Bacteriophages - genetics; Cluster analysis; Clustered Regularly Interspaced Short Palindromic Repeats; Clustering; CRISPR; CRISPR‐Cas; Databases, Protein; Gastrointestinal Microbiome; Humans; Models, Molecular; Operons; Protein Conformation; Protein structure; Proteins; Sequences; Similarity; structure similarity; Tools for Protein Science; Viral Proteins - chemistry; Viral Proteins - genetics; Viral Proteins - metabolism; virome; virome; CRISPR‐Cas; anti‐CRISPR; anti‐defense genes; bacterial immunity; structure similarity

Anti‐CRISPR (Acr) proteins play a key role in phage‐host interactions and hold great promise for advancing genome‐editing technologies. However, finding new Acrs has been challenging due to their low sequence similarity. Recent advances in protein structure prediction have opened new pathways for Ac...