NAD+ acts on mitochondrial SirT3 to prevent axonal caspase activation and axonal degeneration

• Published in: The FASEB journal Vol. 27; no. 12; p. 4712
• Main Authors: Magnifico, Sébastien, Saias, Laure, Deleglise, Bérangère, Duplus, Eric, Kilinc, Devrim, Miquel, Marie-Christine, Viovy, Jean-Louis, Brugg, Bernard, Peyrin, Jean-Michel
• Format: Journal Article
• Language: English
• Published: United States 01.12.2013
• Subjects: Animals; Apoptosis - drug effects; Axons - drug effects; Axons - metabolism; Caspases - metabolism; Mice; Microfluidics; NAD - pharmacology; Sirtuin 3 - metabolism; Stilbenes - pharmacology; sirtuin; microfluidic; apoptosis

In chronic degenerative syndromes, neuronal death occurs over long periods, during which cells progressively lose their axons and, ultimately, their cell bodies. Although apoptosis is recognized as a key event in neuronal death, the molecular mechanisms involved in CNS axons degeneration are poorly...