Strain difference in the induction of T‐cell activation–associated, interferon gamma–dependent hepatic injury in mice

• Published in: Hepatology (Baltimore, Md.) Vol. 27; no. 2; pp. 513 - 519
• Main Authors: Mizuhara, Hidekazu, Kuno, Masako, Seki, Nobuo, Yu, Wen‐Gong, Yamaoka, Makiko, Yamashita, Masakatsu, Ogawa, Toshikazu, Kaneda, Kenji, Fujii, Takashi, Senoh, Hachiro, Fujiwara, Hiromi
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA W.B. Saunders 01.02.1998; Wiley
• Subjects: Alanine Transaminase - blood; Animals; Biological and medical sciences; Cells, Cultured; Chemical and Drug Induced Liver Injury - etiology; Concanavalin A - pharmacology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression; Genetic Variation; Interferon-gamma - metabolism; Interleukin-2 - metabolism; Liver - drug effects; Liver - metabolism; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Lymphocyte Activation - drug effects; Lymphocyte Activation - physiology; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase Type II; Other diseases. Semiology; RNA, Messenger - analysis; Spleen - drug effects; Spleen - metabolism; Tumor Necrosis Factor-alpha - metabolism; Induction; Liver; Rodentia; Hepatic disease; Lymphokine; Experimental study; In vitro; Vertebrata; Immunology; Mammalia; Cell line; Interleukin 2; Mouse; Animal; T-Lymphocyte; Digestive diseases; Biological effect; Lesion; Tumor necrosis factor α; Gamma interferon

A single intravenous injection of concanavalin A (Con A) induces T‐cell activation–associated inflammatory injury selectively in the liver. This study investigated the strain difference in the development of Con A–induced hepatic injury. Normal C57BL/6 and BALB/c spleen cells produced comparable lev...