Paternal Exposure to Methylphenidate Induces Poor‐Quality Blastocyst and Epigenetic Changes

• Published in: Molecular reproduction and development Vol. 92; no. 5; pp. e70026 - n/a
• Main Authors: Gomes, Ana Clara da Costa Nunes, Pagliari, Laura Eduarda S. C., Stumpp, Taiza, Vendramini, Vanessa
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2025; John Wiley and Sons Inc
• Subjects: Animals; Blastocyst - cytology; Blastocyst - drug effects; Blastocyst - metabolism; Blastocyst - pathology; Blastocysts; DNA fragmentation; embryo; Epigenesis, Genetic - drug effects; Epigenetics; Female; histone methylation; Histones; Histones - metabolism; Immunocytochemistry; Male; Methylphenidate; Methylphenidate - adverse effects; Methylphenidate - pharmacology; Methylphenidate - toxicity; Paternal Exposure - adverse effects; psychostimulant; Rats; Rats, Wistar; spermatozoa; Spermatozoa - drug effects; toxicology; toxicology; histone methylation; embryo; spermatozoa; psychostimulant

ABSTRACT Epigenetic changes caused by methylphenidate hydrochloride on paternal inheritance have been suggested in fish, yet a subject to be determined in mammals. In rats, we showed increased sperm DNA fragmentation and reduced embryonic viability. In the present report, male Wistar rats (n = 21) w...