Clinical Features and Outcomes of Glutamic Acid Decarboxylase‐65 Antibody‐Associated Pure Cerebellar Ataxia and Stiff Person Syndrome Spectrum Disorders: A Single‐Center Cohort Study

• Published in: European journal of neurology Vol. 32; no. 5; pp. e70166 - n/a
• Main Authors: Krett, Jonathan D., Wang, Yujie, Miles, Ashley, Chen, Herbert R., Afshar, Hanyeh, Elfasi, Aisha, Lin, Doris D., Newsome, Scott D.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2025; John Wiley and Sons Inc
• Subjects: Abnormalities; Adult; Aged; Antibodies; Ataxia; Atrophy; Autoantibodies - blood; autoimmune neurology; Benzodiazepines; Cerebellar ataxia; Cerebellar Ataxia - blood; Cerebellar Ataxia - immunology; Cerebellar Ataxia - physiopathology; Cerebellum; Cerebrospinal fluid; Cohort Studies; Encephalomyelitis; Female; GAD‐65; Glutamate decarboxylase; Glutamate Decarboxylase - immunology; Glutamic acid; Humans; Male; Medical imaging; Middle Aged; Myoclonus; Neuroimaging; neuroimmunology; Neurological diseases; Observational studies; Original; Rigidity; Rituximab; stiff person syndrome; Stiff-Person Syndrome - blood; Stiff-Person Syndrome - immunology; Stiff-Person Syndrome - physiopathology; autoimmune neurology; cerebellar ataxia; neuroimmunology; stiff person syndrome; GAD‐65

ABSTRACT Background Cerebellar ataxia is associated with greater disability in glutamic acid decarboxylase‐65 (GAD65) antibody‐associated neurological disorders and can occur in isolation or as part of stiff person syndrome (SPS) spectrum disorders (SPSD). We sought to phenotypically characterize th...