The Impact of Long‐Term Intake of Phenolic Compounds‐Rich Grape Pomace on Rat Gut Microbiota

• Published in: Journal of food science Vol. 83; no. 1; pp. 246 - 251
• Main Authors: Chacar, Stéphanie, Itani, Tarek, Hajal, Joelle, Saliba, Youakim, Louka, Nicolas, Faivre, Jean‐François, Maroun, Richard, Fares, Nassim
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2018; Wiley
• Subjects: Aging; Animals; Antioxidants; Bacteria; Bifidobacterium - isolation & purification; Clostridium; Clostridium - isolation & purification; Clusters; Dilution; Dimethyl sulfoxide; Feces - microbiology; Feeding; Gastrointestinal Microbiome - drug effects; Gastrointestinal Tract - microbiology; gut microbiota; High performance liquid chromatography; Human health and pathology; Intestinal microflora; Lactobacillus - isolation & purification; Life Sciences; Liquid chromatography; Male; Microbiomes; Microbiota; Phenolic compounds; Phenols; Phenols - pharmacology; Plant Extracts - pharmacology; Polymerase chain reaction; Rats; Rats, Wistar; Rodents; Tissues and Organs; Vitis - chemistry; phenolic compounds; gut microbiota; aging

The aim of this work is to evaluate the impact on the rat microbiota of long‐term feeding with phenolic compounds (PC) rich grape pomace extracts. Thirty, 2‐mo‐old rats, were divided into 5 groups. Four groups were treated with different concentrations of PC (2.5, 5, 10, and 20 mg/kg/d diluted in 0....