The Impact of Long‐Term Intake of Phenolic Compounds‐Rich Grape Pomace on Rat Gut Microbiota

The aim of this work is to evaluate the impact on the rat microbiota of long‐term feeding with phenolic compounds (PC) rich grape pomace extracts. Thirty, 2‐mo‐old rats, were divided into 5 groups. Four groups were treated with different concentrations of PC (2.5, 5, 10, and 20 mg/kg/d diluted in 0....

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Published inJournal of food science Vol. 83; no. 1; pp. 246 - 251
Main Authors Chacar, Stéphanie, Itani, Tarek, Hajal, Joelle, Saliba, Youakim, Louka, Nicolas, Faivre, Jean‐François, Maroun, Richard, Fares, Nassim
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.01.2018
Wiley
Subjects
Aging
Animals
Antioxidants
Bacteria
Bifidobacterium - isolation & purification
Clostridium
Clostridium - isolation & purification
Clusters
Dilution
Dimethyl sulfoxide
Feces - microbiology
Feeding
Gastrointestinal Microbiome - drug effects
Gastrointestinal Tract - microbiology
gut microbiota
High performance liquid chromatography
Human health and pathology
Intestinal microflora
Lactobacillus - isolation & purification
Life Sciences
Liquid chromatography
Male
Microbiomes
Microbiota
Phenolic compounds
Phenols
Phenols - pharmacology
Plant Extracts - pharmacology
Polymerase chain reaction
Rats
Rats, Wistar
Rodents
Tissues and Organs
Vitis - chemistry
phenolic compounds
gut microbiota
aging
Online AccessGet full text

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Abstract The aim of this work is to evaluate the impact on the rat microbiota of long‐term feeding with phenolic compounds (PC) rich grape pomace extracts. Thirty, 2‐mo‐old rats, were divided into 5 groups. Four groups were treated with different concentrations of PC (2.5, 5, 10, and 20 mg/kg/d diluted in 0.1% DMSO), and 1 group received 0.1% Dimethyl Sulfoxide (DMSO) alone (control group). The daily treatment lasted 14 mo. Major phenolic compounds constituents were characterized by the high‐performance liquid chromatography and free radical scavenging capacity was measured by means of the DPPH assay. Fecal samples from young rats (2‐mo old), and rats daily fed with PC or DMSO were collected at 6 and 14 mo posttreatment. The gut microbiota composition was analyzed by quantitative polymerase chain reaction. Bifidobacterium was significantly higher in the groups PC 2.5 and PC 5 than in control and young rats. Lactobacillus decreased with time in all treated and untreated groups. Bacteroides, Clostridium leptum subgroup (Clostridium cluster IV), and Enterococcus were not significantly changed by PC at any concentration when compared to control; nevertheless, after 14 mo of treatment all concentrations of PC abolished the increase of Clostridium sensu stricto (cluster I) (Clostridium Cluster I) observed in the control group when compared to young rats. PC do modulate selectively rat gut microbiome to a healthier phenotype in long‐term feeding rats, and could counteract the adverse outcomes of aging on gut bacterial population. Practical Application This research shows that phenolic‐rich grape pomace extracts exhibiting a high antioxidant activity, selectively modulate rat gut microbiota to a healthier phenotype within age in a long‐term feeding rats.
AbstractList The aim of this work is to evaluate the impact on the rat microbiota of long-term feeding with phenolic compounds (PC) rich grape pomace extracts. Thirty, 2-mo-old rats, were divided into 5 groups. Four groups were treated with different concentrations of PC (2.5, 5, 10, and 20 mg/kg/d diluted in 0.1% DMSO), and 1 group received 0.1% Dimethyl Sulfoxide (DMSO) alone (control group). The daily treatment lasted 14 mo. Major phenolic compounds constituents were characterized by the high-performance liquid chromatography and free radical scavenging capacity was measured by means of the DPPH assay. Fecal samples from young rats (2-mo old), and rats daily fed with PC or DMSO were collected at 6 and 14 mo posttreatment. The gut microbiota composition was analyzed by quantitative polymerase chain reaction. Bifidobacterium was significantly higher in the groups PC 2.5 and PC 5 than in control and young rats. Lactobacillus decreased with time in all treated and untreated groups. Bacteroides, Clostridium leptum subgroup (Clostridium cluster IV), and Enterococcus were not significantly changed by PC at any concentration when compared to control; nevertheless, after 14 mo of treatment all concentrations of PC abolished the increase of Clostridium sensu stricto (cluster I) (Clostridium Cluster I) observed in the control group when compared to young rats. PC do modulate selectively rat gut microbiome to a healthier phenotype in long-term feeding rats, and could counteract the adverse outcomes of aging on gut bacterial population. This research shows that phenolic-rich grape pomace extracts exhibiting a high antioxidant activity, selectively modulate rat gut microbiota to a healthier phenotype within age in a long-term feeding rats.
The aim of this work is to evaluate the impact on the rat microbiota of long-term feeding with phenolic compounds (PC) rich grape pomace extracts. Thirty, 2-mo-old rats, were divided into 5 groups. Four groups were treated with different concentrations of PC (2.5, 5, 10, and 20 mg/kg/d diluted in 0.1% DMSO), and 1 group received 0.1% Dimethyl Sulfoxide (DMSO) alone (control group). The daily treatment lasted 14 mo. Major phenolic compounds constituents were characterized by the high-performance liquid chromatography and free radical scavenging capacity was measured by means of the DPPH assay. Fecal samples from young rats (2-mo old), and rats daily fed with PC or DMSO were collected at 6 and 14 mo posttreatment. The gut microbiota composition was analyzed by quantitative polymerase chain reaction. Bifidobacterium was significantly higher in the groups PC 2.5 and PC 5 than in control and young rats. Lactobacillus decreased with time in all treated and untreated groups. Bacteroides, Clostridium leptum subgroup (Clostridium cluster IV), and Enterococcus were not significantly changed by PC at any concentration when compared to control; nevertheless, after 14 mo of treatment all concentrations of PC abolished the increase of Clostridium sensu stricto (cluster I) (Clostridium Cluster I) observed in the control group when compared to young rats. PC do modulate selectively rat gut microbiome to a healthier phenotype in long-term feeding rats, and could counteract the adverse outcomes of aging on gut bacterial population. Practical Application This research shows that phenolic-rich grape pomace extracts exhibiting a high antioxidant activity, selectively modulate rat gut microbiota to a healthier phenotype within age in a long-term feeding rats.
The aim of this work is to evaluate the impact on the rat microbiota of long-term feeding with phenolic compounds (PC) rich grape pomace extracts. Thirty, 2-mo-old rats, were divided into 5 groups. Four groups were treated with different concentrations of PC (2.5, 5, 10, and 20 mg/kg/d diluted in 0.1% DMSO), and 1 group received 0.1% Dimethyl Sulfoxide (DMSO) alone (control group). The daily treatment lasted 14 mo. Major phenolic compounds constituents were characterized by the high-performance liquid chromatography and free radical scavenging capacity was measured by means of the DPPH assay. Fecal samples from young rats (2-mo old), and rats daily fed with PC or DMSO were collected at 6 and 14 mo posttreatment. The gut microbiota composition was analyzed by quantitative polymerase chain reaction. Bifidobacterium was significantly higher in the groups PC 2.5 and PC 5 than in control and young rats. Lactobacillus decreased with time in all treated and untreated groups. Bacteroides, Clostridium leptum subgroup (Clostridium cluster IV), and Enterococcus were not significantly changed by PC at any concentration when compared to control; nevertheless, after 14 mo of treatment all concentrations of PC abolished the increase of Clostridium sensu stricto (cluster I) (Clostridium Cluster I) observed in the control group when compared to young rats. PC do modulate selectively rat gut microbiome to a healthier phenotype in long-term feeding rats, and could counteract the adverse outcomes of aging on gut bacterial population. PRACTICAL APPLICATIONThis research shows that phenolic-rich grape pomace extracts exhibiting a high antioxidant activity, selectively modulate rat gut microbiota to a healthier phenotype within age in a long-term feeding rats.
The aim of this work is to evaluate the impact on the rat microbiota of long‐term feeding with phenolic compounds (PC) rich grape pomace extracts. Thirty, 2‐mo‐old rats, were divided into 5 groups. Four groups were treated with different concentrations of PC (2.5, 5, 10, and 20 mg/kg/d diluted in 0.1% DMSO), and 1 group received 0.1% Dimethyl Sulfoxide (DMSO) alone (control group). The daily treatment lasted 14 mo. Major phenolic compounds constituents were characterized by the high‐performance liquid chromatography and free radical scavenging capacity was measured by means of the DPPH assay. Fecal samples from young rats (2‐mo old), and rats daily fed with PC or DMSO were collected at 6 and 14 mo posttreatment. The gut microbiota composition was analyzed by quantitative polymerase chain reaction. Bifidobacterium was significantly higher in the groups PC 2.5 and PC 5 than in control and young rats. Lactobacillus decreased with time in all treated and untreated groups. Bacteroides, Clostridium leptum subgroup (Clostridium cluster IV), and Enterococcus were not significantly changed by PC at any concentration when compared to control; nevertheless, after 14 mo of treatment all concentrations of PC abolished the increase of Clostridium sensu stricto (cluster I) (Clostridium Cluster I) observed in the control group when compared to young rats. PC do modulate selectively rat gut microbiome to a healthier phenotype in long‐term feeding rats, and could counteract the adverse outcomes of aging on gut bacterial population. Practical Application This research shows that phenolic‐rich grape pomace extracts exhibiting a high antioxidant activity, selectively modulate rat gut microbiota to a healthier phenotype within age in a long‐term feeding rats.
Author Saliba, Youakim
Fares, Nassim
Faivre, Jean‐François
Chacar, Stéphanie
Itani, Tarek
Maroun, Richard
Hajal, Joelle
Louka, Nicolas
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  givenname: Youakim
  surname: Saliba
  fullname: Saliba, Youakim
  organization: Univ. Saint Joseph
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  fullname: Louka, Nicolas
  organization: Univ. Saint‐Joseph
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  givenname: Jean‐François
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  surname: Fares
  fullname: Fares, Nassim
  email: nassim.fares@usj.edu.lb
  organization: Univ. Saint Joseph
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Issue 1
Keywords phenolic compounds
gut microbiota
aging
Language English
License 2017 Institute of Food Technologists®.
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Lakshminarayanan B (e_1_2_8_14_1) 2013; 62
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Snippet The aim of this work is to evaluate the impact on the rat microbiota of long‐term feeding with phenolic compounds (PC) rich grape pomace extracts. Thirty,...
The aim of this work is to evaluate the impact on the rat microbiota of long-term feeding with phenolic compounds (PC) rich grape pomace extracts. Thirty,...
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StartPage 246
SubjectTerms Aging
Animals
Antioxidants
Bacteria
Bifidobacterium - isolation & purification
Clostridium
Clostridium - isolation & purification
Clusters
Dilution
Dimethyl sulfoxide
Feces - microbiology
Feeding
Gastrointestinal Microbiome - drug effects
Gastrointestinal Tract - microbiology
gut microbiota
High performance liquid chromatography
Human health and pathology
Intestinal microflora
Lactobacillus - isolation & purification
Life Sciences
Liquid chromatography
Male
Microbiomes
Microbiota
Phenolic compounds
Phenols
Phenols - pharmacology
Plant Extracts - pharmacology
Polymerase chain reaction
Rats
Rats, Wistar
Rodents
Tissues and Organs
Vitis - chemistry
Title The Impact of Long‐Term Intake of Phenolic Compounds‐Rich Grape Pomace on Rat Gut Microbiota
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2F1750-3841.14006
https://www.ncbi.nlm.nih.gov/pubmed/29227528
https://www.proquest.com/docview/1986194847
https://search.proquest.com/docview/1975592332
https://hal.science/hal-03715801
Volume 83
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