Linperlisib causing high blood sugar and hyponatremia, leading to facial nerve paralysis and muscle nerve damage: A rare case report

• Published in: Medicine (Baltimore) Vol. 104; no. 24; p. e42875
• Main Authors: Jiang, Yu-cai, Zhao, Cheng-fei, Zheng, Lin-lin
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 13.06.2025
• Subjects: Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Blood Glucose; Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors; Clinical Case Report; Enzyme Inhibitors - adverse effects; Enzyme Inhibitors - therapeutic use; Facial Nerve Diseases - chemically induced; Facial Paralysis - chemically induced; Facial Paralysis - diagnosis; Humans; Hyperglycemia - chemically induced; Hyperglycemia - diagnosis; Hyponatremia - chemically induced; Hyponatremia - diagnosis; Lymphoma, T-Cell, Peripheral - drug therapy; Male; Middle Aged; facial palsy; hyperglycemia; myalgia; linperlisib; hyponatremia

Rationale: Linperlisib is a highly selective small-molecule inhibitor of phosphatidylinositol-3-kinase delta for the treatment of relapsed/refractory follicular lymphoma. Patient concerns: The patient was a 64-year-old male with peripheral T-cell lymphoma and diabetes mellitus who experienced hyperg...