Production and metabolism of platelet-activating factor in the normal and ischemic fetal rat brain

• Published in: Journal of neurochemistry Vol. 63; no. 6; p. 2144
• Main Authors: Kunievsky, B, Yavin, E
• Format: Journal Article
• Language: English
• Published: England 01.12.1994
• Subjects: Animals; Biological Assay; Blood Platelets - drug effects; Blood Platelets - metabolism; Brain - drug effects; Brain - embryology; Brain - metabolism; Calcimycin - pharmacology; Choline - metabolism; Half-Life; Ischemic Attack, Transient - metabolism; Kinetics; Phosphatidylinositol Phosphates - metabolism; Platelet Activating Factor - analogs & derivatives; Platelet Activating Factor - biosynthesis; Platelet Activating Factor - metabolism; Platelet Activating Factor - pharmacology; Rats; Rats, Wistar; Serotonin - blood; Tritium; Type C Phospholipases - metabolism

Production and metabolism of platelet-activating factor (PAF) in the fetal rat brain under normal and under ischemic stress conditions were examined. Endogenous PAF levels, determined by a bioassay using PAF-stimulated platelet release of [3H]serotonin, averaged 2.32 +/- 2.14 pg/mg in control brains...