l‐carnitine decreases glycolysis in liquid‐stored platelets

• Published in: Transfusion (Philadelphia, Pa.) Vol. 40; no. 11; pp. 1313 - 1319
• Main Authors: Sweeney, Joseph D., Blair, Abbe‐Jane, Cheves, Tracey A., Dottori, Secondo, Arduini, Arduino
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Inc 01.11.2000; Blackwell Publishing
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Platelets - metabolism; Blood Preservation; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Carnitine - pharmacology; Cryopreservation; Dose-Response Relationship, Drug; ESC = extent of shape change; Glycolysis - drug effects; HSR = hypotonic shock response; LAC = l‐acetyl‐carnitine; LC = l‐carnitine; Medical sciences; PC(s) = platelet concentrate(s); PRP = platelet‐rich plasma; Time Factors; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Human; Liquid state; Blood cell; Platelet; Storage; Preservation; Glycolysis; Levocarnitine; Concentrate; Conditioning; Technique; Metabolism

BACKGROUND: The platelet storage lesion is characterized metabolically by a pH decrease associated with lactic acid generation; a change in platelet morphology from discoid to spherical; a diminished response to in vitro challenge tests, such as the hypotonic shock response (HSR) and extent of shape...