Pretrichodermamide A Biosynthesis Reveals the Hidden Diversity of Epidithiodiketopiperazines

• Published in: Angewandte Chemie International Edition Vol. 62; no. 18; pp. e202217212 - n/a
• Main Authors: Fan, Jie, Ran, Huomiao, Wei, Peng‐Lin, Li, Yuanyuan, Liu, Huan, Li, Shu‐Ming, Hu, Youcai, Yin, Wen‐Bing
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 24.04.2023
• Edition: International ed. in English
• Subjects: Alkaloids; biochemical pathways; Biosynthesis; Chemical reactions; DNA methylation; Enzyme Catalysis; Enzymes; Epoxidation; Fungi; furans; genes; Hydroxylation; methyltransferases; Methyltransferases - metabolism; Models, Molecular; Molecular Structure; Natural products; Oxazine; Oxazines - chemistry; oxidoreductases; Reductases; regioselectivity; Substrate Promiscuity; Substrates; Trichoderma; Fungi; Alkaloids; Biosynthesis; Enzyme Catalysis; Substrate Promiscuity

Fungal epidithiodiketopiperazines (ETPs) possess large structural diversity and complexity due to modifications of the cyclodipeptide skeleton. Elucidation of the biosynthetic pathway of pretrichodermamide A (1) in Trichoderma hypoxylon revealed a flexible catalytic machinery of multiple enzymes for...