Association between life's essential 8 and colorectal cancer: A population-based study
Colorectal cancer (CRC) is closely linked to cardiovascular disease. This study investigates the relationship between life's essential 8 (LE8), a recent cardiovascular health metric, and CRC prevalence in US adults. Data from the 2011 to 2018 National Health and Nutrition Examination Survey wer...
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| Published in | Medicine (Baltimore) Vol. 104; no. 27; p. e43261 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Hagerstown, MD
Lippincott Williams & Wilkins
04.07.2025
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| Abstract | Colorectal cancer (CRC) is closely linked to cardiovascular disease. This study investigates the relationship between life's essential 8 (LE8), a recent cardiovascular health metric, and CRC prevalence in US adults. Data from the 2011 to 2018 National Health and Nutrition Examination Survey were used in this study. LE8 was classified into high, moderate, and low levels. The association between LE8 and CRC was assessed using weighted logistic regression, restricted cubic splines, and subgroup analyses. After adjusting for potential confounders, higher LE8 scores were linked to a lower prevalence of CRC. Individuals with the highest LE8 scores had an 81% reduced risk of CRC compared to those with the lowest scores (odds ratio = 0.19; 95% confidence interval: 0.04-0.88, P = .03). Restricted cubic splines analyses revealed a negative correlation between CRC risk and LE8 scores, showing a linear decline as LE8 scores increased (P for non-linearity > .05). LE8 was inversely associated with CRC prevalence in a linear manner. Encouraging adherence to optimal cardiovascular health may help reduce CRC burden. |
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| AbstractList | Colorectal cancer (CRC) is closely linked to cardiovascular disease. This study investigates the relationship between life’s essential 8 (LE8), a recent cardiovascular health metric, and CRC prevalence in US adults. Data from the 2011 to 2018 National Health and Nutrition Examination Survey were used in this study. LE8 was classified into high, moderate, and low levels. The association between LE8 and CRC was assessed using weighted logistic regression, restricted cubic splines, and subgroup analyses. After adjusting for potential confounders, higher LE8 scores were linked to a lower prevalence of CRC. Individuals with the highest LE8 scores had an 81% reduced risk of CRC compared to those with the lowest scores (odds ratio = 0.19; 95% confidence interval: 0.04–0.88, P = .03). Restricted cubic splines analyses revealed a negative correlation between CRC risk and LE8 scores, showing a linear decline as LE8 scores increased ( P for non-linearity > .05). LE8 was inversely associated with CRC prevalence in a linear manner. Encouraging adherence to optimal cardiovascular health may help reduce CRC burden. Colorectal cancer (CRC) is closely linked to cardiovascular disease. This study investigates the relationship between life’s essential 8 (LE8), a recent cardiovascular health metric, and CRC prevalence in US adults. Data from the 2011 to 2018 National Health and Nutrition Examination Survey were used in this study. LE8 was classified into high, moderate, and low levels. The association between LE8 and CRC was assessed using weighted logistic regression, restricted cubic splines, and subgroup analyses. After adjusting for potential confounders, higher LE8 scores were linked to a lower prevalence of CRC. Individuals with the highest LE8 scores had an 81% reduced risk of CRC compared to those with the lowest scores (odds ratio = 0.19; 95% confidence interval: 0.04–0.88, P = .03). Restricted cubic splines analyses revealed a negative correlation between CRC risk and LE8 scores, showing a linear decline as LE8 scores increased ( P for non-linearity > .05). LE8 was inversely associated with CRC prevalence in a linear manner. Encouraging adherence to optimal cardiovascular health may help reduce CRC burden. Colorectal cancer (CRC) is closely linked to cardiovascular disease. This study investigates the relationship between life's essential 8 (LE8), a recent cardiovascular health metric, and CRC prevalence in US adults. Data from the 2011 to 2018 National Health and Nutrition Examination Survey were used in this study. LE8 was classified into high, moderate, and low levels. The association between LE8 and CRC was assessed using weighted logistic regression, restricted cubic splines, and subgroup analyses. After adjusting for potential confounders, higher LE8 scores were linked to a lower prevalence of CRC. Individuals with the highest LE8 scores had an 81% reduced risk of CRC compared to those with the lowest scores (odds ratio = 0.19; 95% confidence interval: 0.04-0.88, P = .03). Restricted cubic splines analyses revealed a negative correlation between CRC risk and LE8 scores, showing a linear decline as LE8 scores increased (P for non-linearity > .05). LE8 was inversely associated with CRC prevalence in a linear manner. Encouraging adherence to optimal cardiovascular health may help reduce CRC burden.Colorectal cancer (CRC) is closely linked to cardiovascular disease. This study investigates the relationship between life's essential 8 (LE8), a recent cardiovascular health metric, and CRC prevalence in US adults. Data from the 2011 to 2018 National Health and Nutrition Examination Survey were used in this study. LE8 was classified into high, moderate, and low levels. The association between LE8 and CRC was assessed using weighted logistic regression, restricted cubic splines, and subgroup analyses. After adjusting for potential confounders, higher LE8 scores were linked to a lower prevalence of CRC. Individuals with the highest LE8 scores had an 81% reduced risk of CRC compared to those with the lowest scores (odds ratio = 0.19; 95% confidence interval: 0.04-0.88, P = .03). Restricted cubic splines analyses revealed a negative correlation between CRC risk and LE8 scores, showing a linear decline as LE8 scores increased (P for non-linearity > .05). LE8 was inversely associated with CRC prevalence in a linear manner. Encouraging adherence to optimal cardiovascular health may help reduce CRC burden. |
| Author | Zhang, Xiaofei Lan, Xuan Chen, Sheng Zhang, Xinyue Peng, Jing Hou, Encun Ma, Xiaohan Wu, Fasheng |
| Author_xml | – sequence: 1 givenname: Xiaohan surname: Ma fullname: Ma, Xiaohan organization: Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China – sequence: 2 givenname: Xiaofei surname: Zhang fullname: Zhang, Xiaofei email: 3578316045@qq.com organization: Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China – sequence: 3 givenname: Fasheng surname: Wu fullname: Wu, Fasheng email: 840766676@qq.com organization: Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China – sequence: 4 givenname: Sheng surname: Chen fullname: Chen, Sheng email: 13005909276@163.com organization: Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China – sequence: 5 givenname: Jing surname: Peng fullname: Peng, Jing email: 2107533055@qq.com organization: Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China – sequence: 6 givenname: Xuan surname: Lan fullname: Lan, Xuan email: 742618462@qq.com organization: Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China – sequence: 7 givenname: Xinyue surname: Zhang fullname: Zhang, Xinyue email: 3578316045@qq.com organization: Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China – sequence: 8 givenname: Encun surname: Hou fullname: Hou, Encun email: enunhou123@163.com organization: Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China |
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| Cites_doi | 10.3322/caac.21492 10.1038/s41575-020-00368-3 10.1161/CIR.0000000000000579 10.1016/j.ijsu.2014.07.013 10.1016/j.ajpc.2022.100452 10.1016/j.envres.2017.03.036 10.1016/S2468-1253(21)00426-X 10.1002/acr.24730 10.1016/j.canep.2016.01.004 10.1016/j.cpcardiol.2022.101540 10.4093/dmj.2021.0077 10.1146/annurev-publhealth-031210-101218 10.1186/s12916-023-02824-8 10.1371/journal.pmed.1002834 10.1016/j.cgh.2021.01.037 10.1093/occmed/kqq008 10.1053/euhj.1999.1990 10.1186/s12967-022-03839-0 10.1093/jnci/djac011 10.1002/cncr.26677 10.1161/CIRCULATIONAHA.117.030816 10.1038/nature13398 10.1016/j.orcp.2012.12.002 10.1161/JAHA.121.023438 10.1038/ajg.2011.301 10.1097/CEJ.0000000000000578 10.1161/CIR.0000000000001078 10.1016/j.jand.2018.05.021 10.1159/000533257 10.1016/j.heliyon.2023.e23872 10.1210/er.2018-00154 |
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| Issue | 27 |
| Keywords | the National Health and Nutrition Examination Survey risk factors colorectal cancer life's essential 8 life’s essential 8 |
| Language | English |
| License | http://creativecommons.org/licenses/by/4.0 Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| Notes | Received: 17 April 2024 / Received in final form: 18 June 2025 / Accepted: 20 June 2025 The study was supported by the construction project of the National Flagship Department of Integrative Medicine (Department of Oncology, Ruikang Hospital, Guangxi University of Traditional Chinese Medicine). The research protocol for NHANES received formal approval from the Institutional Review Board of the National Center for Health Statistics (NCHS), with written informed consent obtained from all participating individuals. As the current investigation constitutes a secondary analysis of deidentified, publicly available NHANES data, it was classified as exempt from further institutional review board evaluation according to established ethical guidelines for secondary data analysis. The authors have no conflicts of interest to disclose. The datasets generated during and/or analyzed during the current study are publicly available. How to cite this article: Ma X, Zhang X, Wu F, Chen S, Peng J, Lan X, Zhang X, Hou E. Association between life's essential 8 and colorectal cancer: A population-based study. Medicine 2025;104:27(e43261). XM and XZ contributed equally to this work. *Correspondence: Encun Hou, Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530011, Guangxi, China (e-mail: enunhou123@163.com). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| Snippet | Colorectal cancer (CRC) is closely linked to cardiovascular disease. This study investigates the relationship between life's essential 8 (LE8), a recent... Colorectal cancer (CRC) is closely linked to cardiovascular disease. This study investigates the relationship between life’s essential 8 (LE8), a recent... |
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| SubjectTerms | Adult Aged Colorectal Neoplasms - epidemiology Cross-Sectional Studies Female Humans Male Middle Aged Nutrition Surveys Observational Study Prevalence Risk Factors United States - epidemiology |
| Title | Association between life's essential 8 and colorectal cancer: A population-based study |
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