Synthesis of Polylactide‐Based Core–Shell Interface Cross‐Linked Micelles for Anticancer Drug Delivery

• Published in: Macromolecular bioscience Vol. 17; no. 3; pp. np - n/a
• Main Authors: Chen, Chih‐Kuang, Lin, Wei‐Jen, Hsia, Yu, Lo, Leu‐Wei
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.03.2017
• Subjects: Biodegradable materials; biodegradable polymers; Biodegradation; Bioplastics; Cell Line, Tumor; cross‐linked micelles; Cytotoxicity; Doxorubicin - administration & dosage; Doxorubicin - chemical synthesis; drug delivery; Drug Delivery Systems; Female; Humans; Irradiation; Micelles; nanocarriers; Physiology; Polyesters - administration & dosage; Polyesters - chemical synthesis; polylactide; Sarcoma; Sarcoma - drug therapy; Sarcoma - pathology; Uterine Neoplasms - drug therapy; Uterine Neoplasms - pathology; drug delivery; polylactide; cross-linked micelles; biodegradable polymers; nanocarriers

Well‐defined poly(ethylene glycol)‐b‐allyl functional polylactide‐b‐polylactides (PEG‐APLA‐PLAs) are synthesized through sequential ring‐opening polymerization. PEG‐APLA‐PLAs that have amphiphilic properties and reactive allyl side chains on their intermediate blocks are successfully transferred to...