Functional hierarchy of PCNA‐interacting motifs in DNA processing enzymes

• Published in: BioEssays Vol. 45; no. 6; pp. e2300020 - n/a
• Main Authors: Hamdan, Samir M., De Biasio, Alfredo
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2023
• Subjects: active sites; Chemical synthesis; cryo‐EM; Deoxyribonucleic acid; DNA; DNA - genetics; DNA biosynthesis; DNA ligases; DNA polymerase; DNA Polymerase III - chemistry; DNA Polymerase III - genetics; DNA Polymerase III - metabolism; DNA polymerases; DNA Replication; DNA-directed DNA polymerase; DNA-Directed DNA Polymerase - metabolism; Enzymes; ligases; Okazaki fragments maturation; Proliferating cell nuclear antigen; Proliferating Cell Nuclear Antigen - chemistry; Proliferating Cell Nuclear Antigen - genetics; Proliferating Cell Nuclear Antigen - metabolism; Protein Binding; Structure-function relationships; Substrates; proliferating cell nuclear antigen; DNA polymerases; Okazaki fragments maturation; DNA replication; DNA ligases; cryo-EM

Numerous eukaryotic DNA processing enzymes, such as DNA polymerases and ligases, bind the processivity factor PCNA, which acts as a platform to recruit and regulate the binding of enzymes to their DNA substrate. Multiple PCNA‐interacting motifs (PIPs) are present in these enzymes, but their individu...