Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas

• Published in: Medical oncology (Northwood, London, England) Vol. 31; no. 7; pp. 14 - 11
• Main Authors: Wu, Jianyuan, Li, Qingdi Quentin, Zhou, Huiping, Lu, Yinying, Li, Jueli M., Ma, Yao, Wang, Li, Fu, Tingting, Gong, Xingjiang, Weintraub, Michael, Wu, Shuangchan, Ding, Hong
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.07.2014; Springer Nature B.V
• Subjects: Antineoplastic Agents, Alkylating - pharmacology; Apoptosis - drug effects; Apoptosis - physiology; bcl-2-Associated X Protein - metabolism; Caspases - metabolism; Cell Cycle Checkpoints - drug effects; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Diterpenes - pharmacology; Epoxy Compounds - pharmacology; Female; Genes, p53; Hematology; Humans; Internal Medicine; Medicine; Medicine & Public Health; Mitochondria - drug effects; Mitochondria - metabolism; Mutation; Oncology; Original Paper; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Pathology; Phenanthrenes - pharmacology; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Triptolide; Antitumor drug; Cell cycle; Ovarian cancer; Apoptosis; p53

Triptolide is a traditional Chinese medicinal herb-derived antineoplastic agent. However, its antitumor activity against gynecologic carcinomas has not yet been well described. It is the purpose of this article to investigate the effect and mechanism of triptolide in human ovarian cancer using both...