Induction of fetal haemoglobin expression in erythroid cells – A model based on iron availability signalling

• Published in: Medical hypotheses Vol. 65; no. 5; pp. 932 - 936
• Main Authors: Delgado-Cañedo, A., Chies, J.A.B., Nardi, N.B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 2005
• Subjects: Aclarubicin - administration & dosage; Antibiotics, Antineoplastic - administration & dosage; Cell Differentiation - drug effects; Dose-Response Relationship, Drug; Doxorubicin - administration & dosage; Fetal Hemoglobin - biosynthesis; Gene Expression Regulation, Neoplastic - drug effects; Humans; K562 Cells; Models, Biological; Neoplasm Proteins - metabolism; Signal Transduction - drug effects
• ISSN: 0306-9877; 1532-2777
• DOI: 10.1016/j.mehy.2005.02.046

The K562 cell line has erythroid origin and is used for the study of fetal haemoglobin (HbF) production after treatment with several drugs, such as hydroxyurea, cisplatin and cytosine arabinoside (Ara C). It represents an important tool for the study of cancer differentiation therapy and treatment o...