Analysis of Nonrandomly Censored Ordered Categorical Longitudinal Data from Analgesic Trials

• Published in: Journal of the American Statistical Association Vol. 92; no. 440; pp. 1235 - 1244
• Main Authors: Sheiner, Lewis B., Beal, Stuart L., Dunne, Adrian
• Format: Journal Article
• Language: English
• Published: Washington Taylor & Francis Group 01.12.1997; American Statistical Association
• Subjects: Analgesia; Analgesics; Applications and Case Studies; Conditional model; Dosage; Dropout; Drug design; Longitudinal data; Mathematical extrapolation; Missingness; Modeling; Modelling; Non-linear models; Nonignorable nonresponse; Nonlinear regression; Objective functions; Ordered categorical response; Pain; Patients; Pharmacokinetics; Placebos; Random effects; School dropouts; Selection model; Statistical analysis; Statistical methods; Statistical models; Statistics

A clinical trial of an analgesic agent compares pain relief scores over time among groups of patients. All subjects experience the same painful procedure, but different subjects are given different randomly assigned doses of active agent or placebo when they first request it. The data are short indi...