Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity

• Published in: Pathology oncology research Vol. 23; no. 1; pp. 125 - 130
• Main Authors: Oh, Hye Rim, An, Chang Hyeok, Yoo, Nam Jin, Lee, Sug Hyung
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 2017; Springer Nature B.V
• Subjects: Apoptosis - genetics; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinogenesis - genetics; Colorectal Neoplasms - genetics; DNA Mutational Analysis - methods; DNA, Neoplasm - genetics; Frameshift Mutation - genetics; Histone Acetyltransferases - genetics; Humans; Immunology; Microsatellite Instability; Microsatellite Repeats - genetics; Oncology; Original Article; Pathology; Stomach Neoplasms - genetics; TATA-Binding Protein Associated Factors - genetics; Transcription Factor TFIID - genetics; Transcription Factors - genetics; TAF1L; Mutation; Microsatellite instability; Basal transcription component; Cancers; TAF1

Initiation of transcription by RNA polymerase II requires TATA-box-binding protein (TBP)-associated factors (TAFs). TAF1 is a major scaffold by which TBP and TAFs interact in the basal transcription factor. TAF1L is a TAF1 homologue with 95 % amino acid identity with TAF1. TAF1 is involved in apopto...