Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population

• Published in: International archives of occupational and environmental health Vol. 89; no. 4; pp. 621 - 628
• Main Authors: Shen, Huanxi, Dou, Jianrui, Han, Lei, Bai, Ying, Li, Qian, Hong, Zhiqiang, Shi, Jian, Zhang, Hengdong, Zhang, Feng, Du, Cheng, Tong, Zhimin, Zhu, Baoli
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2016; Springer Nature B.V
• Subjects: Adult; Case-Control Studies; China - epidemiology; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; Earth and Environmental Science; Environment; Environmental Health; Female; Gene Frequency; Genetic diversity; Genetic Predisposition to Disease - epidemiology; Genetic Predisposition to Disease - genetics; Genotype; Genotype & phenotype; Genotypes; Hearing loss; Hearing Loss, Noise-Induced - epidemiology; Hearing Loss, Noise-Induced - genetics; Humans; Male; Middle Aged; Noise pollution; Noise, Occupational - adverse effects; Occupational Diseases - epidemiology; Occupational Diseases - genetics; Occupational Medicine/Industrial Medicine; Original Article; Polymorphism; Polymorphism, Single Nucleotide; Population genetics; Promoter Regions, Genetic; Rehabilitation; Risk Factors; Polymorphisms; Noise-induced hearing loss susceptibility; APE1

Objective To investigate whether the apurinic/apyrimidinic endonuclease 1 ( APE1 ) 1349 T>G and -656 T>G polymorphisms were associated with the risk of noise-induced hearing loss (NIHL) in a Chinese population. Methods The two APE1 polymorphisms were analyzed among 613 NIHL workers and 613 nor...