Small-animal PET imaging of isolated perfused rat heart

• Published in: Journal of Nuclear Medicine Vol. 55; no. 3; pp. 495 - 499
• Main Authors: Yamane, Tomohiko, Park, Min-Jae, Richter, Dominik, Nekolla, Stephan G, Javadi, Mehrbod S, Lapa, Constantin, Samnick, Samuel, Buck, Andreas K, Herrmann, Ken, Higuchi, Takahiro
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.03.2014
• Subjects: Animals; Correlation analysis; Feasibility Studies; Heart - diagnostic imaging; Heart attacks; Kinetics; Male; Metabolites; Myocardial Infarction - diagnostic imaging; Perfusion; Positron-Emission Tomography - instrumentation; Positron-Emission Tomography - methods; Rats; Rats, Wistar; Rodents; Tissues; Tomography; rat heart; isolated perfused heart; PET; myocardial infarction

The assessment of myocardial radiotracer kinetics, including cardiac extraction fraction and washout, requires the study of isolated perfused hearts to avoid analytic error due to tracer recirculation and systemic metabolites. Analysis of the isolated perfused rat heart by a high-resolution small-an...