The European Biological Variation Study (EuBIVAS): Biological Variation Data for Coagulation Markers Estimated by a Bayesian Model

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 67; no. 9; pp. 1259 - 1270
• Main Authors: Aarsand, Aasne K, Kristoffersen, Ann Helen, Sandberg, Sverre, Støve, Bård, Coşkun, Abdurrahman, Fernandez-Calle, Pilar, Díaz-Garzón, Jorge, Guerra, Elena, Ceriotti, Ferruccio, Jonker, Niels, Røraas, Thomas, Carobene, Anna
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.09.2021
• Subjects: Antithrombin; Bayes Theorem; Bayesian analysis; Biological variation; Biomarkers; Coagulation; Coagulation factors; Dimers; Estimates; Female; Fibrinogen; Fibrinogen - metabolism; Humans; Male; Markers; Men; Partial Thromboplastin Time; Population studies; Protein C; Protein S; Proteins; Prothrombin; Prothrombin Time; Subgroups; Thromboplastin; Variation; Women; analytical performance specification; biological variation; Bayesian model; reference change value; within-subject biological variation

Abstract Background For biological variation (BV) data to be safely used, data must be reliable and relevant to the population in which they are applied. We used samples from the European Biological Variation Study (EuBIVAS) to determine BV of coagulation markers by a Bayesian model robust to extrem...