Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type
Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and prom...
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| Published in | Revista da Sociedade Brasileira de Medicina Tropical Vol. 52; p. e20190101 |
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| Language | English |
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| Abstract | Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) expression. However, the role it exerts on regulatory B cells (CD19+CD24hiCD38hi; Breg) is unknown.
The frequencies of Treg and Breg cells was evaluated and the Th1 profiles were assessed in TSP/HAM patients and healthy control subjects.
Low percentages of Breg cells and high production of IFN-γ were observed in patients compared to those in healthy control subjects.
The low percentage of Breg cells in patients and the increase in the frequency of Th1 cells suggest an imbalance in the control of the inflammatory response that contributes to the immunopathogenesis of TSP/HAM. |
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| AbstractList | Abstract INTRODUCTION: Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) expression. However, the role it exerts on regulatory B cells (CD19+CD24hiCD38hi; Breg) is unknown. METHODS: The frequencies of Treg and Breg cells was evaluated and the Th1 profiles were assessed in TSP/HAM patients and healthy control subjects. RESULTS: Low percentages of Breg cells and high production of IFN-γ were observed in patients compared to those in healthy control subjects. CONCLUSIONS: The low percentage of Breg cells in patients and the increase in the frequency of Th1 cells suggest an imbalance in the control of the inflammatory response that contributes to the immunopathogenesis of TSP/HAM. Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) expression. However, the role it exerts on regulatory B cells (CD19+CD24hiCD38hi; Breg) is unknown. The frequencies of Treg and Breg cells was evaluated and the Th1 profiles were assessed in TSP/HAM patients and healthy control subjects. Low percentages of Breg cells and high production of IFN-γ were observed in patients compared to those in healthy control subjects. The low percentage of Breg cells in patients and the increase in the frequency of Th1 cells suggest an imbalance in the control of the inflammatory response that contributes to the immunopathogenesis of TSP/HAM. Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) expression. However, the role it exerts on regulatory B cells (CD19+CD24hiCD38hi; Breg) is unknown.INTRODUCTIONTropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) expression. However, the role it exerts on regulatory B cells (CD19+CD24hiCD38hi; Breg) is unknown.The frequencies of Treg and Breg cells was evaluated and the Th1 profiles were assessed in TSP/HAM patients and healthy control subjects.METHODSThe frequencies of Treg and Breg cells was evaluated and the Th1 profiles were assessed in TSP/HAM patients and healthy control subjects.Low percentages of Breg cells and high production of IFN-γ were observed in patients compared to those in healthy control subjects.RESULTSLow percentages of Breg cells and high production of IFN-γ were observed in patients compared to those in healthy control subjects.The low percentage of Breg cells in patients and the increase in the frequency of Th1 cells suggest an imbalance in the control of the inflammatory response that contributes to the immunopathogenesis of TSP/HAM.CONCLUSIONSThe low percentage of Breg cells in patients and the increase in the frequency of Th1 cells suggest an imbalance in the control of the inflammatory response that contributes to the immunopathogenesis of TSP/HAM. |
| Author | Paz, Angie Vanessa Caicedo Caldon, Cristhian Camilo Rivera Constain, Juan Sebastián Rodríguez Gonzáles, Gloria Inés Ávila Castaño, Victoria Eugenia Niño Marin-Agudelo, Nancy Burbano, Yulieth Cristina Bermúdez Dueñas-Cuellar, Rosa Amalia Hernández, Julio César Klínger |
| AuthorAffiliation | University of Cauca Washington University in St. Louis |
| AuthorAffiliation_xml | – name: Washington University in St. Louis – name: University of Cauca |
| Author_xml | – sequence: 1 givenname: Yulieth Cristina Bermúdez surname: Burbano fullname: Burbano, Yulieth Cristina Bermúdez organization: University of Cauca, Colombia – sequence: 2 givenname: Angie Vanessa Caicedo surname: Paz fullname: Paz, Angie Vanessa Caicedo organization: University of Cauca, Colombia – sequence: 3 givenname: Cristhian Camilo Rivera surname: Caldon fullname: Caldon, Cristhian Camilo Rivera organization: University of Cauca, Colombia – sequence: 4 givenname: Juan Sebastián Rodríguez surname: Constain fullname: Constain, Juan Sebastián Rodríguez organization: University of Cauca, Colombia – sequence: 5 givenname: Gloria Inés Ávila surname: Gonzáles fullname: Gonzáles, Gloria Inés Ávila organization: University of Cauca, Colombia – sequence: 6 givenname: Julio César Klínger surname: Hernández fullname: Hernández, Julio César Klínger organization: University of Cauca, Colombia – sequence: 7 givenname: Nancy surname: Marin-Agudelo fullname: Marin-Agudelo, Nancy organization: Washington University School of Medicine, USA – sequence: 8 givenname: Rosa Amalia surname: Dueñas-Cuellar fullname: Dueñas-Cuellar, Rosa Amalia organization: University of Cauca, Colombia – sequence: 9 givenname: Victoria Eugenia Niño orcidid: 0000-0002-7726-3613 surname: Castaño fullname: Castaño, Victoria Eugenia Niño organization: University of Cauca, Colombia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31340370$$D View this record in MEDLINE/PubMed |
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| Keywords | HTLV-1 virus Regulatory B cells Regulatory T cells Interferon-γ Tropical Spastic Paraparesis |
| Language | English |
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| Snippet | Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects... Abstract INTRODUCTION: Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1... |
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| SubjectTerms | Adolescent B-Lymphocytes, Regulatory - immunology B-Lymphocytes, Regulatory - virology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Female HTLV-1 virus Humans Interferon-gamma - immunology Interferon-γ Male Paraparesis, Tropical Spastic - immunology Paraparesis, Tropical Spastic - virology Regulatory B cells Regulatory T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - virology TROPICAL MEDICINE Tropical Spastic Paraparesis Viral Load |
| Title | Low Frequency Of Regulatory B-Cells And Increased CD4+ and CD8+ Interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31340370 https://www.proquest.com/docview/2264221246 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100325&lng=en&tlng=en https://doaj.org/article/53dce96626c3400a9aa6b612253ca93c |
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