Fabrication of core-shell nanofibers for controlled delivery of bromelain and salvianolic acid B for skin regeneration in wound therapeutics

• Published in: Biomedical materials (Bristol) Vol. 12; no. 3; p. 035005
• Main Authors: Shoba, Ekambaram, Lakra, Rachita, Syamala Kiran, Manikantan, Korrapati, Purna Sai
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 05.06.2017
• Subjects: Absorption, Physicochemical; Administration, Cutaneous; Animals; Benzofurans - administration & dosage; Benzofurans - chemistry; bromelain; Bromelains - administration & dosage; Bromelains - chemistry; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - chemical synthesis; Diffusion; Drug Combinations; Electroplating - methods; electrospinning; Female; Lacerations - drug therapy; Lacerations - pathology; Nanocapsules - chemistry; Nanocapsules - ultrastructure; nanofiber; Nanofibers - chemistry; Nanofibers - ultrastructure; Rats; Rats, Wistar; Regeneration - drug effects; salvianolic acid B; Skin - drug effects; Skin - growth & development; Skin - pathology; Treatment Outcome; wound healing; Wound Healing - drug effects

The physiological and pathological complexity of the wound healing process makes it more challenging to design an ideal tissue regeneration scaffold. Precise scaffolding with high drug loading efficiency, efficient intracellular efficacy for therapeutic delivery, minimal nonspecific cellular and blo...